57182-86-2

Basic information

• Product Name: 6-dimethylamino-9-[3'-(O-methyl) (2S)-N-benzyloxycarbonyltyrosinylamino-3'-deoxy-β-D-ribofuranosyl]purine
• Synonyms: 6-dimethylamino-9-[3'-(O-methyl) (2S)-N-benzyloxycarbonyltyrosinylamino-3'-deoxy-β-D-ribofuranosyl]purine
• CAS NO: 57182-86-2
• Molecular Weight: 605.651
• Mol File: 57182-86-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-dimethylamino-9-[3'-(O-methyl) (2S)-N-benzyloxycarbonyltyrosinylamino-3'-deoxy-β-D-ribofuranosyl]purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-dimethylamino-9-[3'-(O-methyl) (2S)-N-benzyloxycarbonyltyrosinylamino-3'-deoxy-β-D-ribofuranosyl]purine(57182-86-2)
• EPA Substance Registry System: 6-dimethylamino-9-[3'-(O-methyl) (2S)-N-benzyloxycarbonyltyrosinylamino-3'-deoxy-β-D-ribofuranosyl]purine(57182-86-2)

Safety Data

• Hazardous Substances Data: 57182-86-2(Hazardous Substances Data)

Upstream product

• 17554-34-6 (2S)-2-[(benzyloxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid 
• 58-60-6 3'-amino-3'-deoxy-N⁶,N⁶-dimethyladenosine 
• 501-53-1 benzyl chloroformate 
• 60-18-4 L-tyrosine 
• 1164-16-5 Z-L-Tyr-OH 

Downstream Products

• 53-79-2 puromycin 
• 87007-38-3 C₆₄H₇₀N₉O₁₆P 

Relevant articles and documents

Synthesis of 6-Dimethylamino-9-[3'-(O-Methyl) (2S)-[UL-14C]Tyrosinylamino)-3'-Deoxy-β-D- ribofuranosyl] purine

In order to investigate and further refine the mechanism of the unique cleavage activity of the 18 amino acid 2A region of the foot-and-mouth-disease virus (FMDV), the synthesis of 14C-labelled puromycin is required. Puromycin is an inhibitor of protein synthesis and is an analogue of the terminal aminoacyl-adenosine portion of aminoacyl-tRNA. A short and expedient four step synthesis of 6-dimethylamino-9-[3'-(O-methyl) (2S)-[UL-14C]tyrosinylamino)-3'-deoxy-β-D-ribofuranos purine (14C-labelled puromycin) starting from (2S)-[UL-14C]-tyrosine is therefore described.