5719-34-6Relevant articles and documents
MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS
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Page/Page column 42; 56, (2013/04/24)
The invention relates to compounds of formula (I) wherein m, o, Ra, Rb, R1 and T1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and selective iGluR5 modulators
Butini, Stefania,Pickering, Darryl S.,Morelli, Elena,Coccone, Salvatore Sanna,Trotta, Francesco,De Angelis, Meri,Guarino, Egeria,Fiorini, Isabella,Campiani, Giuseppe,Novellino, Ettore,Schousboe, Arne,Christensen, Jeppe K.,Gemma, Sandra
supporting information; experimental part, p. 6614 - 6618 (2009/10/17)
(S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.
Synthesis of Cyclic and Acyclic Nucleoside Analogues Having a Thiophene or Dihydrothiophene Ring Fused to the d Side of an Uracil
Jourdan, Fabrice,Renault, Jacques,Karamat, Abdesselam,Ladurie, Daniel,Robba, Max
, p. 953 - 958 (2007/10/02)
Synthesis of cyclic and acyclic nucleosides was achieved by alkylation of various new aglycones following the Vorbrueggen and Niedballa's procedure .The analytical results allowed us to conclude that the alkylation ocurred on N1 site led to the β anomeric form for the cyclic nucleosides.