57198-04-6Relevant articles and documents
A 1/10 water ribavirin compounds and pharmaceutical compositions thereof (by machine translation)
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Paragraph 0052; 0055; 0056, (2019/01/23)
The invention discloses a 1/10 water ribavirin compounds and pharmaceutical compositions thereof, per mole of ribavirin compounds containing 1/10 mole water. Its infrared spectrum in the wave number is 3451.8 ± 2 cm- 1 , 3347.5 ± 2 cm- 1 , 2857.1 ± 2 cm- 1 , 1663.3 ± 2 cm- 1 , 1502.8 ± 2 cm- 1 , 1438.4 ± 2 cm- 1 , 1336.8 ± 2 cm- 1 , 1281.8 ± 2 cm- 1 , 1070.3 ± 2 cm- 1 , 892.8 ± 2 cm- 1 , 773.3 ± 2 cm- 1 , 672.0 ± 2 cm- 1 There is a characteristic absorption peak. The invention through crystallization of the ribavirin impact factors study and research of different crystallization solvent system, to prepare high purity, good stability 1/10 water RBV compound, and by this invention stated 1/10 water RBV compound preparation has good stability of the pharmaceutical composition. (by machine translation)
The use of a four-acetyl ribose nucleoside cracking after crystallization of the raffinate and method
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Paragraph 0048; 0063; 0065, (2018/03/09)
The invention discloses a method for using tetraacetylribose crystallization residual liquor after splitting decomposition of nucleoside. The tetraacetylribose crystallization residual liquor after splitting decomposition of nucleoside is residual crystallization mother liquor after preparation of 1,2,3,5-tetra-O-acetyl-beta-D-furan ribose through catalytic acylation splitting decomposition and recrystallization of nucleoside, wherein the mother liquor contains 1,2,3,5-tetra-O-acetyl-alpha-D-furan ribose. The method comprises the following steps: extracting the tetraacetylribose crystallization residual liquor after splitting decomposition of nucleoside by using an extraction solution to obtain 1,2,3,5-tetra-O-acetyl-alpha-D-furan ribose; then carrying out condensation reaction with 1,2,4-triazole-3-carboxylic acid methyl ester under the action of a catalyst to prepare a ribavirin condensation compound 1-(2,3,5-tri-O-acetyl-beta-D-furanribosyl)-1H-1,2,4-3-carboxylic acid methyl ester; and carrying out ammonolysis on the ribavirin condensation compound to obtain ribavirin. The method disclosed by the invention turns waste into wealth and treats and converts tetraacetylribose crystallization mother liquor produced in an existing process, so that the discharge of waste liquor in a production process of tetraacetylribose is reduced.
A RBV aminolysis reaction abolishes solvent method (by machine translation)
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Paragraph 0010; 0011; 0012, (2016/10/24)
This invention involves a kind of RBV aminolysis reaction abolishes solvent virulences method, the method is to RBV intermediate reaction the liquid ammonia ribavirin condensation compound, extremely high purity by crude ribavirin. The process of the invention eliminate the toxicity solvent methanol, without long-term open ammonia, nor need concentrated methanol, reaction time is short, simple and convenient operation, liquid ammonia can be applied repeatedly, energy-saving and emission reduction, environmental protection, the product purity, high yield, low cost, it is more suitable for large scale industrial production, and the like, has obvious implementation value and social, economic benefits. (by machine translation)
