57212-27-8

Basic information

• Product Name: N-methyl-N-m-tolylbenzamide
• Synonyms: N-methyl-N-m-tolylbenzamide
• CAS NO: 57212-27-8
• Molecular Weight: 225.29
• Mol File: 57212-27-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-methyl-N-m-tolylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-m-tolylbenzamide(57212-27-8)
• EPA Substance Registry System: N-methyl-N-m-tolylbenzamide(57212-27-8)

Safety Data

• Hazardous Substances Data: 57212-27-8(Hazardous Substances Data)

Upstream product

• 696-44-6 N-methyl-m-toluidine 
• 2996-92-1 phenyl trimethylsiloxane 
• 98-88-4 benzoyl chloride 
• 121-72-2 N,N-dimethyl-m-toluidine 
• 37952-93-5 N-benzoyl saccharin 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 101663-45-0 N-benzyl-N,3-dimethylaniline 
• 582-77-4 3'-methylbenzanilide 

Relevant articles and documents

Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C-N Bond Cleavage

Palladium-catalyzed Hiyama coupling of active thioureas via selective C-N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF 2as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.

Copper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant

An unprecedented N-demethylation of N-methyl amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.

Palladium-catalyzed aminocarbonylation of aryl iodides with amides and N-alkyl anilines

A novel and efficient palladium-catalyzed aminocarbonylation of aryl iodides with amides and N-alkyl anilines has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the rapid synthesis of a variety of valuable imides and tertiary benzanilides under an atmospheric pressure of CO. Copyright