57226-61-6

Basic information

• Product Name: nisoxetine
• CAS NO: 57226-61-6
• Molecular Formula: C17H21NO2
• Molecular Weight: 271.35414
• Mol File: 57226-61-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: nisoxetine(CAS DataBase Reference)
• NIST Chemistry Reference: nisoxetine(57226-61-6)
• EPA Substance Registry System: nisoxetine(57226-61-6)

Safety Data

• Hazardous Substances Data: 57226-61-6(Hazardous Substances Data)

Upstream product

• 57226-60-5 3-chloro-1-(o-methoxyphenoxy)propylbenzene 
• 74-89-5 methylamine 
• 104-52-9 phenylpropyl chloride 
• 21763-00-8 1-bromo-3-chloro-1-phenylpropane 
• 766-51-8 2-Chloroanisole 
• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 
• 114446-52-5 -(-)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane 
• 191733-29-6 (S)-N-(ethoxycarbonyl)-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine 
• 96-09-3 styrene oxide 
• 73627-97-1 3-hydroxy-3-phenylpropanenitrile 
• 138750-31-9 (1R)-3-amino-1-phenyl-1-propanol 
• 198561-42-1 (R)-3-acetyloxy-3-phenylpropanenitrile 
• 502697-62-3 (R)-(3-hydroxy-3-phenylpropyl)carbamic acid ethyl ester 
• 936-59-4 3-chloropropiophenone 

Relevant articles and documents

Method for synthesizing chiral secondary alcohol compound

The invention discloses a method for synthesizing a chiral secondary alcohol compound. The method comprises the following step of: reacting a ketone compound in an aprotic organic solvent at room temperature and inert gas atmosphere under the action of a chiral cobalt catalyst and an activating agent by taking a combination of bis(pinacolato)diboron and alcohol or water as a reducing agent to obtain the chiral secondary alcohol compound. According to the method disclosed by the invention, a combination of pinacol diborate and alcohol or water which are cheap, stable and easy to obtain is taken as a reducing agent, and a ketone compound is efficiently reduced to synthesize a corresponding chiral secondary alcohol compound in an aprotic organic solvent under the action of a chiral cobalt catalyst; in a chiral cobalt catalyst adopted by the method, when a chiral ligand is PAOR, an activating agent is NaBHEt3 or NaOtBu and an adopted raw material is aromatic ketone, the yield is 80% or above, and the optical purity is 90% or above; and when the adopted raw material is alkane ketone, the yield can reach 70% or above, and the optical purity can reach 80% or above.

A method for preparing optically active 3-amino-1-phenylpropanol derivatives as an intermediate and a method for preparing optically active pharmaceutical products using the same

The present invention relates to a method for preparing a 3-amino-1-phenylpropanol derivative having (R) or (S) optical activity with 80% or more of an enantiomeric excess (ee), which includes a step of performing an asymmetric reduction reaction in the presence of a spiroborate ester catalyst and a hydrogen donor. The invention also relates to a method for preparing an optically active pharmaceutical product, which includes a step of preparing a (R)- or (S)-3-amino-1-phenylpropanol derivative, that is an intermediate, by using the catalyst.(AA) 3-amino-1-phenylpropanol(BB) Tomoxetine(CC) Nisoxetine(DD) FluoxetineCOPYRIGHT KIPO 2016

Chemoenzymatic asymmetric synthesis of fluoxetine, atomoxetine, nisoxetine, and duloxetine

The asymmetric synthesis of two well-known anti-depressant drugs, fluoxetine and duloxetine has been accomplished in a chemoenzymatic manner. The main highlight of the synthesis is the enantioselective cyanohydrin formation by a plant (R)-HNL (hydroxynitrile lyase). The enantiopure cyanohydrins are then synthetically manipulated into the above two drug molecules and two of their structural analogues, atomoxetine and nisoxetine.