57230-04-3Relevant articles and documents
Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof
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, (2022/01/04)
Described herein are compounds, pharmaceutical compositions and methods of using these compounds and pharmaceutical compositions for treating and/or preventing conditions such as amyotrophic lateral sclerosis. These compounds and pharmaceutical compositions are also useful as antivirals and antimicrobial agents.
A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions
Huang, Guan-Jhong,Bhaskar Reddy, M. Vijaya,Kuo, Ping-Chung,Huang, Chieh-Hung,Shih, Hung-Cheng,Lee, E.-Jian,Yang, Mei-Lin,Leu, Yann-Lii,Wu, Tian-Shung
experimental part, p. 371 - 378 (2012/03/26)
In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.
Compositions containing aromatic aldehydes and their use in treatments
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, (2008/06/13)
Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.