57235-84-4

Basic information

• Product Name: 1H-Tetrazole, 5-(chloromethyl)-1-methyl-
• Synonyms: 5-chloromethyl-1-methyl-tetrazole;5-Chlormethyl-1-methyl-1H-tetrazol;5-chloromethyl-1-methyl-1H-tetrazole;1-methyl-5-chloromethyl-1,2,3,4-tetrazole
• CAS NO: 57235-84-4
• Molecular Formula: C3H5ClN4
• Molecular Weight: 132.55200
• Mol File: 57235-84-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Tetrazole, 5-(chloromethyl)-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Tetrazole, 5-(chloromethyl)-1-methyl-(57235-84-4)
• EPA Substance Registry System: 1H-Tetrazole, 5-(chloromethyl)-1-methyl-(57235-84-4)

Safety Data

• Hazardous Substances Data: 57235-84-4(Hazardous Substances Data)

Usage

Chemical class

Tetrazoles, which are organic compounds containing a 5-member ring made up of four nitrogen atoms and one carbon atom.

Molecular structure

A methyl group attached to the first nitrogen atom of the tetrazole ring and a chloromethyl group attached to the fifth carbon atom.

Usage

Commonly used in chemical research and organic synthesis as a versatile building block for the preparation of various pharmaceuticals, agrochemicals, and materials.

Reactivity

The chloromethyl and methyl groups present in the compound can be further modified through chemical reactions to introduce specific functionalities.

Value in synthesis

A valuable intermediate in the production of diverse chemical compounds due to its reactivity and ability to introduce specific functionalities.

Potential applications

Unique structure and reactivity make it a useful tool for the synthesis of new molecules with potential applications in various fields.

Upstream product

• 96-30-0 chloroacetylmethylamide 
• 186581-53-3 diazomethane 
• 55408-11-2 5-chloromethyl-1H-tetrazole 
• 10026-13-8 phosphorus pentachloride 
• 71-43-2 benzene 
• 55408-11-2 5-(chloromethyl)-2H-1,2,3,4-tetrazole 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1280294-13-4 C₁₄H₁₈N₄O₅ 

Relevant articles and documents

A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group

Abstract: A convenient method is proposed for constructing the tetrazole ring by a one-pot reaction of amides with phosphorus oxychloride and sodium azide. A series of 1,5-disubstituted tetrazoles containing an amino or a carboxy group, which present interest as buildings blocks for the synthesis of biologically active substances, were obtained.

NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME

Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n-Z-(CH2)m—PO(OR7)(OR8), —(CH2)nZ-(CH2)m—PO(OR7)Rg, —(CH2)n-Z-(CH2)m—OPO(OR7)Rg, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10);R5 and R6 are independently selected from H, alkyl and halogen;Y is R7(CH2)s or is absent; andX, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

The tetrazolylmethyl and related radicals: A convenient access to tetrazoles and other heterocyclic derivatives

The tetrazole unit can be simply introduced by addition of the 5- tetrazolmethyl radical to a variety of terminal olefins using the xanthate transfer technology; the same principle can be applied to other heterocyclic systems such as imidazoles and benzothiazoles.