57237-97-5

Basic information

• Product Name: Timoprazole
• Synonyms: Timoprazole;2-[(2-Pyridylmethyl)sulfinyl]-1H-benzimidazole;2-(pyridin-2-ylmethylsulfinyl)-1H-benzimidazole
• CAS NO: 57237-97-5
• Molecular Formula: C₁₃H₁₁N₃OS
• Molecular Weight: 257.31
• Mol File: 57237-97-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 540.3°Cat760mmHg
• Flash Point: 280.6°C
• Appearance: /
• Density: 1.45g/cm³
• Vapor Pressure: 9.65E-12mmHg at 25°C
• Refractive Index: 1.751
• PKA: pKa 3.12 (Uncertain);8.82 (Uncertain)
• CAS DataBase Reference: Timoprazole(CAS DataBase Reference)
• NIST Chemistry Reference: Timoprazole(57237-97-5)
• EPA Substance Registry System: Timoprazole(57237-97-5)

Safety Data

• Hazardous Substances Data: 57237-97-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H11N3OS/c17-18(9-10-5-3-4-8-14-10)13-15-11-6-1-2-7-12(11)16-13/h1-8H,9H2,(H,15,16)

Upstream product

• 132750-25-5 2-<(2-pyridinylmethyl)thio>-1-(morpholinylmethyl)benzimidazole 
• 23593-23-9 2-(Pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole; hydrochloride 
• 23593-22-8 2-{[(pyridin-2-yl)methyl]thio}-1H-benzimidazole 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 134469-07-1 Benzimidazol-2-thiol 
• 4377-33-7 2-chloromethylpyridine 

Downstream Products

• 51290-77-8 2-(benzylthio)-1H-benzo[d]imidazole 
• 110143-87-8 2-Benzyldisulfanylmethyl-pyridine 
• 14610-11-8 2-(ethylsulfanyl)-1H-benzimidazole 
• 110143-86-7 2-Ethyldisulfanylmethyl-pyridine 
• 2360-29-4 2-(phenylsulfanyl)-1H-benzimidazole 
• 110143-85-6 2-Benzenesulfinyl-1H-benzoimidazole 
• 104340-32-1 (benzimidazol-2-yl) benzyl sulfoxide 

Relevant articles and documents

Enhanced Antigiardial Effect of Omeprazole Analog Benzimidazole Compounds

Giardiasis is a diarrheal disease that is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; however, failures in drug therapy are common, and have adverse effects and increased resistance of the parasite to the drug, generating the need to find new alternative treatments. In this study, we synthesized a series of 2-mercaptobenzimidazoles that are derivatives of omeprazole, and the chemical structures were confirmed through mass, 1H NMR, and 13C NMR techniques. The in vitro efficacy compounds against Giardia, as well as its effect on the inhibition of triosephosphate isomerase (TPI) recombinant, were investigated, the inactivation assays were performed with 0.2 mg/mL of the enzyme incubating for 2 h at 37 ?C in TE buffer, pH 7.4 with increasing concentrations of the compounds. Among the target compounds, H-BZM2, O2N-BZM7, and O2N-BZM9 had greater antigiardial activity (IC50: 36, 14, and 17 μM on trophozoites), and inhibited the TPI enzyme (K2: 2.3, 3.2, and 2.8 M?1 s?1) respectively, loading alterations on the secondary structure, global stability, and tertiary structure of the TPI protein. Finally, we demonstrated that it had low toxicity on Caco-2 and HT29 cells. This finding makes it an attractive potential starting point for new antigiardial drugs.

Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group

A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ε-phthalimidoperhexanoic acid is particularly useful for the preparation of compounds of industrial interest, in particular pharmaceuticals for human or veterinary use.

Studies on (H+-K+)-ATPase Inhibitors of Gastric Acid Secretion. Prodrugs of 2-benzimidazole Proton-Pump Inhibitors

The synthesis of N-substituted benzimidazole (H+-K+)-ATPase or proton-pump inhibitors is described.These compounds were prepared to function as prodrugs of the parent N-H compound and evaluated for their ability to inhibit gastric (H