5724-15-2

Basic information

• Product Name: N,N,N-trimethyl-3-oxo-3-phenylpropan-1-aminium iodide
• CAS NO: 5724-15-2
• Molecular Formula: C₁₂H₁₈NO*I
• Molecular Weight: 319.1819
• Mol File: 5724-15-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N,N-trimethyl-3-oxo-3-phenylpropan-1-aminium iodide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N,N-trimethyl-3-oxo-3-phenylpropan-1-aminium iodide(5724-15-2)
• EPA Substance Registry System: N,N,N-trimethyl-3-oxo-3-phenylpropan-1-aminium iodide(5724-15-2)

Safety Data

• Hazardous Substances Data: 5724-15-2(Hazardous Substances Data)

Upstream product

• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 74-88-4 methyl iodide 
• 98-86-2 acetophenone 

Downstream Products

• 5650-34-0 2,3-epoxy-1-phenylpropan-1-one 
• 101733-95-3 phenyl-(6-phenyl-3,4-dihydro-2H-pyran-2-yl)-ketone oxime 
• 124383-42-2 3-(4,5α-epoxy-3,6α-dihydroxy-morphin-7-en-17-yl)-1-phenyl-propan-1-one 
• 55563-72-9 3-methoxy-1-phenylpropan-1-one 
• 47457-70-5 C₁₉H₂₂N₄O₂ 
• 1162-19-2 3-(4-furan-2-yl-4-hydroxy-3-methyl-piperidin-1-yl)-1-phenyl-propan-1-one 
• 89228-95-5 3-Phenyl-2-propyl-cyclohex-2-enone 
• 89228-97-7 2-Isobutyl-3-phenyl-cyclohex-2-enone 
• 89228-96-6 2-butyl-3-phenyl-2-cyclohexenone 
• 80541-58-8 methyl 2-isobutyryl-5-oxo-5-phenylpentanoate 
• 92050-04-9 diethyl 3'-oxo-3'-phenylpropyl(phenyl)malonate 
• 768-03-6 Phenyl vinyl ketone 
• 89228-94-4 2-Ethyl-3-phenyl-cyclohex-2-enone 
• 58337-98-7 1,2,5-triphenylpentane-1,5-dione 

Relevant articles and documents

Syntheses and stability studies of some Mannich bases of acetophenones and evaluation of their cytotoxicity against Jurkat cells

Mannich bases, namely 1-aryl-3-dimethylamino-1-propanone hydrochlorides (Ia-f) as mono-Mannich bases (series I), bis(β-axoylethyl)ethylamine hydrochlorides (IIa, IIb, IId, IIe) as bis-Mannich bases (series II), 3-aroyl-4-aryl-1-ethyl-4-piperidinol hydrochlorides (series III), which axe structural isomers of bis derivatives and some representative quaternary salts (Ig, IIIf, IIIg), were synthesized to investigate the effect of chemical structure and ring substituents on cytotoxic activity in Jurkat cells. Stability studies of some representative compounds have also been realised. Compounds IIb, IId, IIe, and IIIe were reported for the first time. Id-g, IIa, IId, IIe, IIIf,g were 1.25-6.55 times more potent than 5-fluorouracil (CAS 51-21-8). However, the cytotoxic activity of the most potent compounds, Ig and IIIf, were one fifth of that of melphalan (CAS 148-82-3). The formation of compound IV during the stability studies of Ig, IIa, and IIIf suggested that they may be thiol alkylators. Bis-Mannich base IIa in non-substituted derivatives, piperidinol derivative IIIb in methyl substituted compounds, mono derivative Id in chloro substituted compounds were the most potent compounds when the cytotoxicity of the compound series which have the same substituents in benzene ring are compared. Replacement of the benzene with thiophene improved the cytotoxicity in both series I and II. Quaternization procedure also increased the cytotoxicity in both series I and III. Quaternary derivatives seem to be promising compounds for further studies to develop new anticancer drugs.

Novel 6-substituted 8-azabicyclo [3.2.1.] octanes as potential opiate agonists and antagonists

Reaction of 8-methyl-8-azabicyclo[3.2.1]octan-6-one (tropan-6-one) with aryl magnesium halides selectively yields 6β-aryl-6α-hydroxy-8-methyl-8-azabicyclo[3.2.1]octanes (6β-aryl-6α-hydroxytropanes). 1H nmr studies supporting the assignment are presented, together with 13C data of these alcohols and various derivatives prepared as potential agonists and antagonists of opiate receptors. The results from 1H nmr studies of 6-hydroxytropan-3-one, the synthesis of which was reported in 1952, support the assigned 6β-hydroxy stereochemistry.