57248-64-3

Basic information

• Product Name: 4,5-dichloro-3H-1,2-dithiole-3-thione
• Synonyms: 4,5-dichloro-3H-1,2-dithiole-3-thione;3H-1,2-dithiole-3-thione, 4,5-dichloro-;4,5-dichloro-1,2-dithiole-3-thione;4,5-dichloro-3-dithiolethione;4,5-dichlorodithiole-3-thione;A4352/0185687
• CAS NO: 57248-64-3
• Molecular Formula: C₃Cl₂S₃
• Molecular Weight: 203.1331
• Mol File: 57248-64-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-dichloro-3H-1,2-dithiole-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dichloro-3H-1,2-dithiole-3-thione(57248-64-3)
• EPA Substance Registry System: 4,5-dichloro-3H-1,2-dithiole-3-thione(57248-64-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 57248-64-3(Hazardous Substances Data)

Upstream product

• 1192-52-5 dichloro-1,2-dithiacyclopentenone 
• 62-55-5 thioacetamide 

Downstream Products

• 848029-39-0 chloro-(4,5-dibenzoyl-[1,3]dithiol-2-ylidene)-thioacetyl chloride 
• 1227697-25-7 2-(chloro)ethane-2-[4-(phenylimino)-1,3-dithietan-2-ylidene]thioyl chloride 
• 1227697-26-8 2-(chloro)ethane-2-{4-[(4-methoxyphenyl)imino]-1,3-di-thietan-2-ylidene}thioyl chloride 
• 1227697-24-6 2-(chloro)ethane-2-[({(4-methylphenyl)sulfonyl}-methylimino)-1,3-dithietan-2-ylidene]thioyl chloride 
• 1227697-27-9 2-(chloro)ethane-2-{4-[(4-nitrophenyl)imino]-1,3-dithietan-2-ylidene}thioyl chloride 

Relevant articles and documents

Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents

Nucleophilic substitution of a chlorine atom in 4,5 dichloro-1,2-dithiole-3-thione with per-O-acetyl-1-mercaptho derivatives of d-glucose, d-galactose, d-mannose, d-xylose, l-arabinose, and d-maltose gave six new acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione. These thioglycosides were shown to possess cancer preventive activity on the models of JB6 Cl41 P+ mouse epidermal cells and THP-1 human leukemia cells in soft agar, as well as to inhibit the AP-1-dependent transcriptional activity in JB6 Cl41 luc-AP-1 cells, which suggests the possibility of using the new compounds as potential cancer preventive drugs.