57248-88-1 Usage
Description
Pamidronate disodium salt, also known as Disodium pamidronate, is a nitrogen-containing bisphosphonate that functions as a calcium metabolism regulator. It is characterized by its white crystalline appearance and is primarily recognized for its role in the treatment of hypercalcemia associated with malignancy. It achieves this by inhibiting the formation and attachment of osteoclasts, thereby reducing bone resorption of calcium.
Uses
1. Used in Pharmaceutical Industry:
Pamidronate disodium salt is used as a therapeutic agent for the treatment of hypercalcemia associated with malignancy. It helps regulate calcium metabolism by inhibiting osteoclast activity, thus reducing the bone resorption of calcium.
2. Used in Orthopedic Applications:
Pamidronate disodium salt is used as an anti-osteoporotic agent to prevent bone loss and treat osteoporosis. Its ability to inhibit osteoclast activity contributes to the preservation of bone density and strength, making it a valuable asset in combating osteoporosis.
3. Used in Oncology:
As a farnesyl diphosphate synthase inhibitor, Pamidronate disodium salt has potential applications in oncology. It may be utilized in the development of targeted therapies against specific types of cancer by inhibiting the enzyme farnesyl diphosphate synthase, which is involved in the synthesis of isoprenoids essential for cell signaling and growth.
4. Used in Calcitonin-resistant Paget’s Disease:
Pamidronate disodium salt is used as a treatment option for patients with calcitonin-resistant Paget’s disease, a condition characterized by abnormally high bone turnover. Its ability to regulate calcium metabolism and inhibit osteoclast activity makes it a suitable choice for managing this disease.
Originator
Henkel (United Kingdom)
Biochem/physiol Actions
Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Veterinary Drugs and Treatments
Pamidronate may be useful in treating hypercalcemia associated
with vitamin D-related toxicoses or hypercalcemia of malignancy.
There is ongoing research on the use of this drug to determine if
it has clinical usefulness in directly treating “micro-metastases” in
osteosarcomas.
Check Digit Verification of cas no
The CAS Registry Mumber 57248-88-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,2,4 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 57248-88:
(7*5)+(6*7)+(5*2)+(4*4)+(3*8)+(2*8)+(1*8)=151
151 % 10 = 1
So 57248-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
