57260-67-0

Basic information

• Product Name: 1-(3,4-Dichlorophenyl)piperazine
• Synonyms: Piperazine, 1-(3,4-dichlorophenyl)-;1-(3,4-DICHLOROPHENYL)PIPERAZINE;N-(3,4-DICHLOROPHENYL)PIPERAZINE;RARECHEM AH CK 0083;TIMTEC-BB SBB003275;1,2-Dichloro-4-(1-piperazino)benzene;1-(3,4-Dichlorophenyl)piperazine 98%;1-(3,4-DICHLOROPHENYL)-PIPERAZINE >98%
• CAS NO: 57260-67-0
• Molecular Formula: C₁₀H₁₂Cl₂N₂
• Molecular Weight: 231.12
• EINECS: 260-652-9
• Product Categories: PiperazineDerivative;Piperaizine;Piperazine derivates;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Piperazines;PiperazinesHeterocyclic Building Blocks
• Mol File: 57260-67-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 62-66 °C
• Boiling Point: 179 °C (15 mmHg)
• Flash Point: 202°C/15mm
• Appearance: pale yellow crystalline powder
• Density: 1.2949 (rough estimate)
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.6400 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 8.71±0.10(Predicted)
• BRN: 520169
• CAS DataBase Reference: 1-(3,4-Dichlorophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-Dichlorophenyl)piperazine(57260-67-0)
• EPA Substance Registry System: 1-(3,4-Dichlorophenyl)piperazine(57260-67-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-24/25-36
• RIDADR: 3259
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 57260-67-0(Hazardous Substances Data)

Usage

Description

1-(3,4-Dichlorophenyl)piperazine, an N-substituted piperazine, is a pale yellow crystalline powder with a freezing point of 335.65K and a boiling point of 643.73K. It has a density of 1.2949g/cm3 and a refractive index of 1.6400 at 25°C.

Uses

1. Used in Pharmaceutical Industry:
1-(3,4-Dichlorophenyl)piperazine is used as an intermediate compound for the synthesis of various pharmaceutical drugs. Its unique chemical structure allows it to be a key component in the development of medications targeting specific conditions.
2. Used in Chemical Research:
As a versatile chemical compound, 1-(3,4-Dichlorophenyl)piperazine is used as a research tool in the field of chemistry. It aids in understanding the properties and reactions of N-substituted piperazines, contributing to the advancement of chemical knowledge and potential applications.
3. Used in Material Science:
The specific physical and chemical properties of 1-(3,4-Dichlorophenyl)piperazine make it a candidate for use in material science, potentially for the development of new materials with unique properties or for improving existing materials.
4. Used in Analytical Chemistry:
Due to its distinct characteristics, 1-(3,4-Dichlorophenyl)piperazine can be employed as a reference compound or standard in analytical chemistry for calibration and quality control purposes, ensuring accurate measurements and analysis in various chemical processes.

InChI:InChI=1/C10H12Cl2N2/c11-9-2-1-8(7-10(9)12)14-5-3-13-4-6-14/h1-2,7,13H,3-6H2/p+1

Upstream product

• 95-76-1 m,p-dichloroaniline 
• 110-85-0 piperazine 
• 18282-59-2 4-bromo-1,2-dichlorobenzene 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 319926-92-6 tert-butyl 4-(3,4-dichlorophenyl)piperazine-1-carboxylate 
• 20555-91-3 3,4-dichloroiodobenzene 

Downstream Products

• 57260-37-4 2-[4-(3,4-dichloro-phenyl)-piperazin-1-yl]-5-phenyl-oxazol-4-one 
• 57962-01-3 2-{2-[4-(3,4-dichloro-phenyl)-piperazin-1-yl]-ethyl}-quinoline 
• 78069-90-6 1-(3,4-Dichloro-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine 
• 116290-16-5 1-phenoxy-4-[4-(3,4-dichlorophenyl)-1-piperazinyl]-2-butanol 
• 130283-56-6 [4-(3,4-Dichloro-phenyl)-piperazin-1-yl]-((1S,2S)-2-phenoxymethyl-cyclopropyl)-methanone 
• 105277-63-2 7-[3-(4-(3,4-dichlorophenyl)piperazinyl)propoxy]-4H-1-benzopyran-4-one 
• 103247-49-0 2-[4-(3,4-Dichloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-acetamide 
• 120004-63-9 5-{3-[4-(3,4-Dichloro-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 83547-05-1 4-(3,4-dichlorophenyl)-N-(6-methoxy-4-methyl-8-quinolinyl)-1-piperazinehexanamide 
• 117518-18-0 4-(3,4-dichlorophenyl)-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide 
• 1027964-34-6 1-Chloro-3-[4-(3,4-dichloro-phenyl)-piperazin-1-yl]-propan-2-ol 
• 197166-39-5 1-(2,5-dichlorobenzenesulfonyl) 4-(3,4-dichlorophenyl) piperazine 
• 197166-37-3 1-(2,5-dichlorobenzoyl) 4-(3,4-dichlorophenyl) piperazine 

Relevant articles and documents

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

Discovery of imidazole carboxamides as potent and selective CCK1R agonists

High-throughput screening revealed diaryl pyrazole 3 as a selective albeit modest cholecystokinin 1 receptor (CCK1R) agonist. SAR studies led to the discovery and optimization of a novel class of 1,2-diaryl imidazole carboxamides. Compound 44, which was profiled extensively, showed good in vivo mouse gallbladder emptying (mGBE) and lean mouse overnight food intake (ONFI) reduction activities.

Pharmaceutically active pyrrolidine derivatives as bax inhibitors

The present invention is related to new substituted pyrrolidine derivatives of formula (I). Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula (I) are useful in the treatment and/or prevention of neurodegenerative disorders, diseases associated with polygultamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders renal hypoxia, hepatitis and AIDS. Said pyrrolidine derivatives display a modulatory and most notably a down-regulating-up to an inhibitory-activity with respect to the cellular death agonist Bax and/or the activation pathways leading to Bax and allows therefore to block the release of cytochrome (c). The present invention is furthermore related to novel pharmaceutically activity substituted pyrrolidine derivatives as well as to methods of their preparation, wherein X is selected from the group consisting of O, S, CRR, NOR, NNRR; A is selected from the group consisting of —(C═O)—, —(C═O)—O—, —C(═NH)—, —(C═O)—NH—, —(C═S)—NH, —SO2-, —SO2NH—; —CH2-; B is either a group —(C═O)—NRR or represents a heterocyclic residue having the formula (II) wherein Q is NR, O or S; n is an integer selected of 0, 1 or 2; Y, Z and E form together with the 2 carbons to which they are attached a 5-6 membered aryl or heteroaryl ring.