57268-80-1 Usage
Description
[6R-[6alpha,7beta(R)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, also known as a cephalosporin compound, is characterized by its (R)-O-formylmandelamido and N-methylthiotetrazole side groups. This complex molecule is a promising pharmaceutical candidate with potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
[6R-[6alpha,7beta(R)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is used as a prodrug for cefamandole, a widely used antibiotic. As the sodium salt, it serves as an intermediate compound that can be metabolized in the body to produce the active form of the antibiotic, cefamandole, which is effective against a range of bacterial infections.
Used in Research and Development:
In the field of research and development, this cephalosporin compound can be utilized for studying the structure-activity relationships of cephalosporin antibiotics. Understanding the interactions between the compound's side groups and its biological targets can lead to the development of more potent and selective antibiotics with improved pharmacokinetic properties.
Used in Drug Synthesis:
[6R-[6alpha,7beta(R)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid can also be employed as a key intermediate in the synthesis of novel cephalosporin derivatives. By modifying the side groups or incorporating additional functional groups, chemists can create new antibiotics with enhanced properties, such as increased stability, improved bioavailability, or reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 57268-80-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,2,6 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 57268-80:
(7*5)+(6*7)+(5*2)+(4*6)+(3*8)+(2*8)+(1*0)=151
151 % 10 = 1
So 57268-80-1 is a valid CAS Registry Number.
57268-80-1Relevant articles and documents
Method for improving quality of cemandil sodium by using three-dimensional column plate to purify solvent
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Paragraph 0044; 0045; 0051; 0052; 0058; 0059; 0065; 0066, (2017/05/10)
The present invention discloses a method for improving the quality of cemandil sodium by using a three-dimensional column plate to purify a solvent. The method comprises: solvent purification, alkylation reaction, cefamandole ester synthesis, extraction, cemandil sodium synthesis, and sterile sub-packaging. According to the present invention, during the cemandil sodium preparation process, the reaction system solvent is purified by using the high-throughput efficient three-dimensional mass transfer column tray technology so as to finally improve the quality of the cemandil sodium product and ensure the quality of the cemandil sodium powder-needle preparation for injection. The invention provides the method for improving the quality of the cemandil sodium powder-needle preparation for injection by using the three-dimensional column tray mass transfer technology to purify the organic solvent.
PROCESS FOR THE FORMYLATION OF CEFAMANDOLE
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, (2013/05/09)
The present invention relates to a process for the preparation of O-formyl cefamandole, an intermediate in the preparation of cefamandole nafate, by formylation of cefamandole.
