5728-14-3

Basic information

• Product Name: 3-CHLORO-4-PHENYL-1,2,5-THIADIAZOLE
• Synonyms: 3-CHLORO-4-PHENYL-1,2,5-THIADIAZOLE;3-chloro-4-phenyl-1,2,5-thiadiazole(WXC08480)
• CAS NO: 5728-14-3
• Molecular Formula: C₈H₅ClN₂S
• Molecular Weight: 196.66
• Mol File: 5728-14-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 139-144°C
• Boiling Point: 94-96°/0.1mm
• Flash Point: 235.8°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 7.13E-09mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 3-CHLORO-4-PHENYL-1,2,5-THIADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-PHENYL-1,2,5-THIADIAZOLE(5728-14-3)
• EPA Substance Registry System: 3-CHLORO-4-PHENYL-1,2,5-THIADIAZOLE(5728-14-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 5728-14-3(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-phenyl-1,2,5-thiadiazole is a chemical compound with the molecular formula C8H5ClN2S. It is a heterocyclic compound containing a thiadiazole ring with a chlorine atom and a phenyl group attached. 3-CHLORO-4-PHENYL-1,2,5-THIADIAZOLE has potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. It has been studied for its antitumor and antimicrobial properties and is also used as a building block in organic synthesis. 3-Chloro-4-phenyl-1,2,5-thiadiazole is a versatile and important chemical with diverse potential uses.

InChI:InChI=1/C18H24N2OS/c1-2-12-22-18-19-16-11-7-6-10-15(16)17(21)20(18)13-14-8-4-3-5-9-14/h6-7,10-11,14H,2-5,8-9,12-13H2,1H3

Upstream product

• 825-52-5 2-(hydroxyimino)-2-phenylacetonitrile 
• 960-16-7 tributylphenylstannane 
• 5728-20-1 3,4-dichloro-1,2,5-thiadiazole 
• 98-80-6 phenylboronic acid 
• 537706-13-1 3-bromo-4-chloro-1,2,5-thiadiazole 
• 537706-14-2 3-chloro-4-iodo-1,2,5-thiadiazole 
• 140-29-4 phenylacetonitrile 
• 53641-60-4 2-phenylglycinonitrile hydrochloride 
• 4589-97-3 phenylglyoxime 

Downstream Products

• 33710-57-5 4-amino-N-(4-phenyl-[1,2,5]thiadiazol-3-yl)-benzenesulfonamide 
• 33710-58-6 3-amino-4-phenyl-1,2,5-thiadiazole 
• 1048980-26-2 1-hydroxy-4-(4-phenyl-1,2,5-thiadiazol-3-yloxy)-2,2,6,6-tetramethylpiperidine hydrochloride 

Relevant articles and documents

The preparation and characterization of 5-substituted-4-chloro-1,2,3- dithiazolium salts and their conversion into 4-substituted-3-chloro-1,2,5- thiadiazoles

A series of monosubstituted acetonitriles were treated with disulfur dichloride at room temperature in CH2Cl2 to afford 5-substituted-4-chloro-1,2,3-dithiazolium chlorides 1. Where the 5-substituent was not a good leaving group the chloride salts were converted into the corresponding perchlorate salts 2 which were sufficiently stable and soluble to provide both 1H- and 13C-NMR and cyclic voltammetry data. Several of the dithiazolium chlorides were converted into their corresponding 4-substituted-3-chloro-1,2,5-thiadiazoles 13 on treatment with aqueous ammonia. Mechanisms for all reactions are proposed.

HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS

The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates thereof, that bind to Inhibitor of Apoptosis Proteins (IAPs). The compounds of the invention may be used as diagnostic and therapeutic agents in the

Drug Resistance Reversal In Neoplastic Disease

The present invention is directed to compounds, compositions, and methods for halting or reversing the effects of chemoresistance in neoplastic diseases. In particular the use of hydroxylamines is described.