5728-33-6

Basic information

• Product Name: 3'-METHYLBIPHENYL-4-CARBOXYLIC ACID
• Synonyms: 4-(3-METHYLPHENYL)BENZOIC ACID;3'-METHYLBIPHENYL-4-CARBOXYLIC ACID;3'-METHYL [1,1'-BIPHENYL]-4-CARBOXYLIC ACID;AKOS BAR-0004;[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 3'-METHYL-;CHEMBRDG-BB 4400412;RARECHEM AL BE 1342;4-(3-Tolyl)benzoic acid
• CAS NO: 5728-33-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Mol File: 5728-33-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 375.7°Cat760mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.156
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3'-METHYLBIPHENYL-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-METHYLBIPHENYL-4-CARBOXYLIC ACID(5728-33-6)
• EPA Substance Registry System: 3'-METHYLBIPHENYL-4-CARBOXYLIC ACID(5728-33-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 5728-33-6(Hazardous Substances Data)

Usage

Uses

It is used as an active pharmaceutical intermediate.

Upstream product

• 7383-90-6 3,4'-dimethylbiphenyl 
• 89900-94-7 methyl 3'-methyl-[1,1'-biphenyl]-4-carboxylate 
• 93-58-3 benzoic acid methyl ester 
• 108-44-1 1-amino-3-methylbenzene 
• 591-17-3 meta-bromotoluene 
• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 
• 134694-63-6 ethyl 3'-methyl-[1,1'-biphenyl]-4-carboxylate 
• 350792-94-8 (cyclohexyl)(difluoro)(3-methylphenyl)silane 
• 586-76-5 4-Bromobenzoic acid 
• 17933-03-8 m-tolylboronic acid 
• 350792-86-8 (dichloro)(cyclohexyl)(3-methylphenyl)silane 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 619-58-9 4-iodobenzoic acid 

Downstream Products

• 473717-55-4 (10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-(3'-methyl-[1,1'-biphenyl]-4-yl)-methanone 

Relevant articles and documents

Combating fluconazole-resistant fungi with novel β-azole-phenylacetone derivatives

A series of β-azole-phenylacetone derivatives with novel structures were designed and synthesized to combat the increasing incidence of susceptible fungal infections and drug-resistant fungal infections. The antifungal activity of the synthesized compounds was assessed against five susceptible strains and five fluconazole-resistant strains. Antifungal activity tests showed that most of the compounds exhibited excellent antifungal activities against five pathogenic strains with MIC values in the range of 0.03–1 μg/mL. Compounds with R1 = 3-F substituted and 15o and 15ae exhibited moderate antifungal activities against fluconazole-resistant strains 17# and CaR with MIC values in the range of 1–8 μg/mL. Compounds with R1 = H or 2-F (such as 15a, 15o, 15p) displayed moderate to good antifungal activity against fluconazole-resistant strains 632, 901 and 904 with MIC values in the range of 0.125–4 μg/mL. Notably, 15o and 15ae exhibited antifungal activity against five susceptible strains and five fluconazole-resistant strains. Preliminary mechanistic studies showed that the potent antifungal activity of compound 15ae stemmed from inhibition of C. albicans CYP51. Compounds 15o, 15z and 15ae were nearly nontoxic to mammalian A549 cells.

CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS

Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.

An improved protocol for ligandless Suzuki-Miyaura coupling in water

Using a reverse order of addition of reagents, PdCl2 and Pd(OAc)2 are efficient catalysts for the Suzuki-Miyaura reactions in water. The ligandless and mild conditions, the high stability of the catalytic system, short reaction time and good to excellent yields are important features of this protocol.