5728-40-5

Basic information

• Product Name: 2-Chloro-4-phenylbenzoic acid
• Synonyms: 2-Chloro-4-phenylbenzoic acid
• CAS NO: 5728-40-5
• Molecular Formula: C₁₃H₉ClO₂
• Molecular Weight: 232.66236
• Mol File: 5728-40-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-4-phenylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-phenylbenzoic acid(5728-40-5)
• EPA Substance Registry System: 2-Chloro-4-phenylbenzoic acid(5728-40-5)

Safety Data

• Hazardous Substances Data: 5728-40-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-phenylbenzoic acid is a substituted benzoic acid compound with the molecular formula C13H9ClO2. It is commonly used as a building block for organic synthesis and pharmaceuticals. This chemical is known for its potential applications in the development of anti-inflammatory, analgesic, and anti-cancer drugs. Its specific properties and reactivity make it a valuable tool in medicinal and biochemical research. Additionally, 2-Chloro-4-phenylbenzoic acid has been studied for its potential use in the development of new materials and organic electronics.

Upstream product

• 124-38-9 carbon dioxide 
• 91354-08-4 4-bromo-3-chloro-1,1'-biphenyl 
• 5435-92-7 3-chloro-[1,1'-biphenyl]-4-carbonitrile 
• 7285-66-7 3-chlorobiphenyl-4-amine 
• 145343-76-6 2-chloro-4-iodobenzoic acid 
• 1124-19-2 phenyltin trichloride 
• 59748-90-2 4-Bromo-2-chloro-benzoic Acid 
• 98-80-6 phenylboronic acid 

Downstream Products

• 910242-29-4 3-anilino-biphenyl-4-carboxylic acid 
• 857571-73-4 3,10-diphenyl-10H-acridin-9-one 
• 854241-75-1 3-diphenylamino-biphenyl-4-carboxylic acid 

Relevant articles and documents

Design, synthesis, and structure-activity relationship studies of L-amino alcohol derivatives as broad-spectrum antifungal agents

To discover broad spectrum antifungal agents, two strategies were applied, and a novel class of L-amino alcohol derivatives were designed and synthesized. 3-F substituted compounds 14i, 14n, 14s and 14v exhibited excellent antifungal activities with broad antifungal spectra against C. albicans and C. tropicalis, with MIC values in the range of 0.03–0.06 μg/mL, and against A. fumigatus and C. neoformans, with MIC values in the range of 1–2 μg/mL. Notably, Compounds 14i, 14n, 14s and 14v also displayed moderate activities against fluconazole-resistance strains 17# and CaR that were isolated from AIDS patients. Moreover, only compounds in the S-configuration showed antifungal activity. Preliminary mechanistic studies showed that the potent antifungal activity of compound 14v stemmed from inhibition of C. albicans CYP51. Compounds 14n and 14v were almost nontoxic to mammalian A549 cells, and their stability in human plasma was excellent.

Combating fluconazole-resistant fungi with novel β-azole-phenylacetone derivatives

A series of β-azole-phenylacetone derivatives with novel structures were designed and synthesized to combat the increasing incidence of susceptible fungal infections and drug-resistant fungal infections. The antifungal activity of the synthesized compounds was assessed against five susceptible strains and five fluconazole-resistant strains. Antifungal activity tests showed that most of the compounds exhibited excellent antifungal activities against five pathogenic strains with MIC values in the range of 0.03–1 μg/mL. Compounds with R1 = 3-F substituted and 15o and 15ae exhibited moderate antifungal activities against fluconazole-resistant strains 17# and CaR with MIC values in the range of 1–8 μg/mL. Compounds with R1 = H or 2-F (such as 15a, 15o, 15p) displayed moderate to good antifungal activity against fluconazole-resistant strains 632, 901 and 904 with MIC values in the range of 0.125–4 μg/mL. Notably, 15o and 15ae exhibited antifungal activity against five susceptible strains and five fluconazole-resistant strains. Preliminary mechanistic studies showed that the potent antifungal activity of compound 15ae stemmed from inhibition of C. albicans CYP51. Compounds 15o, 15z and 15ae were nearly nontoxic to mammalian A549 cells.

INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.