5728-70-1

Basic information

• Product Name: 4'-Ethyl-[1,1'-biphenyl]-4-amine
• Synonyms: 4'-Ethyl-[1,1'-biphenyl]-4-amine;4'-Ethyl-4-biphenylamine;4-Amino-4′-ethylbiphenyl
• CAS NO: 5728-70-1
• Molecular Formula: C₁₄H₁₅N
• Molecular Weight: 197.28
• Mol File: 5728-70-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 82-83 ºC
• Boiling Point: 333 ºC
• Flash Point: 164 ºC
• Appearance: /
• Density: 1.039
• PKA: 4.31±0.10(Predicted)
• CAS DataBase Reference: 4'-Ethyl-[1,1'-biphenyl]-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Ethyl-[1,1'-biphenyl]-4-amine(5728-70-1)
• EPA Substance Registry System: 4'-Ethyl-[1,1'-biphenyl]-4-amine(5728-70-1)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53-41-37/38
• Safety Statements: 26-37/39-61-60-39
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 5728-70-1(Hazardous Substances Data)

Usage

General Description

4'-Ethyl-[1,1'-biphenyl]-4-amine, also known as 4'-Ethyl-4-aminobiphenyl, is a chemical compound with the molecular formula C14H15N. It is a substituted aniline derivative and belongs to the class of biphenyl compounds. This chemical is commonly used as a starting material in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is known to have potential toxic effects on the liver and immune system and is classified as a possible human carcinogen. It is important to handle this chemical with care and follow safety guidelines when working with it in a laboratory or industrial setting.

Upstream product

• 100-41-4 ethylbenzene 
• 100-65-2 N-Phenylhydroxylamine 

Relevant articles and documents

N- and C-attacks on aromatics of phenylnitrenium ion generated from N-phenylhydroxylamine in the presence of trifluoroacetic acid containing polyphosphoric acid or trifluoroacetic anhydride

A phenylnitrenium ion formed from N-phenylhydroxylamine in the presence of trifluoroacetic acid (TFA) containing polyphosphoric acid (PPA) interacts with the counterion -O2CCF3 and the unshared electron-pair of H2O, showing Hammett's ρ values -5.2 and -4.0 for N- and C-attacks on aromatics PhX (X = H, Me, Et, Ph and Cl), respectively. The ratio N-/C-attack for this nitrenium ion is lower than for the nitrenium ion interacting with only the counterion; the latter nitrenium ion is generated by the use of trifluoroacetic anhydride (TFAA) instead of PPA or by reaction of phenyl azide with aromatics in TFA. The ratio for the former nitrenium ion is affected by the aromatic substituent X:X = Me > X = Et > X = Ph > X = H > X = OMe at 20 and 50°C. The order for X = Cl is between those of X = H and X = Ph at 20°C, but highest at 50°C. The ratio is increased by higher reaction temperature and by decreased concentration of TFA. The results are demonstrated from the mechanistic viewpoint for the nitrenium ions.