57286-93-8 Usage
Description
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol is an alkaloid belonging to the phenethylamine class of alkaloids. It is optically active with a specific rotation of [α]25D 76° and exhibits an ultraviolet spectrum in EtOH with absorption maxima at 225, 274, and 281 nm. (1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol is extracted from the EtOH fraction as the crystalline hydrochloride, which forms colorless needles with a melting point of 144-146°C. The free base form cannot be obtained in a crystalline form.
Uses
Used in Pharmaceutical Industry:
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol is used as an active pharmaceutical ingredient for the development of drugs targeting various medical conditions. Its unique structure and optical activity make it a promising candidate for drug discovery and development.
Used in Chemical Research:
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol is used as a research tool in the field of organic chemistry, particularly in the study of phenethylamine alkaloids and their potential applications in various chemical and biological processes.
Used in Material Science:
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol may be utilized in the development of novel materials with specific optical, electronic, or structural properties due to its unique molecular structure and optical activity.
Used in Analytical Chemistry:
(1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethanol's distinct ultraviolet spectrum can be employed in analytical chemistry for the identification and quantification of similar compounds in complex mixtures, as well as for the development of new analytical methods and techniques.
References
Ranieri, McLaughlin,J. Org. Chem., 41, 319 (1976)
Check Digit Verification of cas no
The CAS Registry Mumber 57286-93-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,2,8 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 57286-93:
(7*5)+(6*7)+(5*2)+(4*8)+(3*6)+(2*9)+(1*3)=158
158 % 10 = 8
So 57286-93-8 is a valid CAS Registry Number.
57286-93-8Relevant articles and documents
Method for synthesizing chiral alpha-amino alcohol compound
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Paragraph 0026; 0042-0045, (2021/07/28)
The invention discloses a method for synthesizing a chiral alpha-amino alcohol compound. The method comprises the following steps: sequentially adding an iron catalyst, a ligand, ketone, an organic solvent and silane into a reaction system at 20-30 DEG C in a nitrogen atmosphere, then stirring the obtained mixture, and carrying out column chromatography separation on the obtained product to obtain a product, namely chiral alpha-amino alcohol. According to the invention, the most high-yield iron catalyst in earth crust is used, and cheap silane (PMHS, 500 g/298 yuan) is adopted as a reducing agent, so the asymmetric reduction reaction of alpha-amino ketone can be efficiently achieved under mild conditions so as to obtain the high-yield optically-active chiral alpha-amino alcohol compound; and moreover, through the creative labor of the inventor, reaction yield can reach 99%, and meanwhile, the content of the target product in the generated reaction product is 99%.
The Asymmetric Aldol Reaction of Tosylmethyl Isocyanide and Aldehydes Catalyzed by Chiral Silver(I) Complexes
Sawamura, Masaya,Hamashima, Hitoshi,Ito, Yoshihiko
, p. 5935 - 5936 (2007/10/02)
The asymmetric aldol reaction of tosylmethyl isocyanide and aldehydes in the presence of 1 mol percent of chiral silver(I) catalysts gave optically active 5-alkyl-4-tosyl-2-oxazolines (up to 86percent ee), which were converted to optically active α-alkyl-β-(N-methylamino)ethanols by LiAlH4 reduction.
