57308-65-3Relevant articles and documents
Synthesis and leukemia cell growth inhibition of a series of 1,3-dithiazolylbenzene derivatives
Lagoja, Irene M.,Nauwelaerts, Koen,Bal-Mahieu, Christine,Pasqualini, Michela,Bailly, Christian,Herdewijn, Piet
, p. 1491 - 1498 (2004)
By a slightly modified Hantzsch thiazole synthesis either 1,3-bis[(thiazol-2-yl)amino]benzene derivatives 2 or 1,3-bis[2-iminothiazol- 3(2H)-yl]benzene derivatives 3 were exclusively obtained. The compounds can be distinguished by NMR spectroscopy. Compounds 2a-2d and 3a-3d were evaluated for their potential antitumor activity, DNA interaction, and for their activity against DNA and RNA viruses and against HIV-1 and HIV-2.
NBS or DEAD as effective reagents in α-thiocyanation of enolizable ketones with ammonium thiocyanate
Reddy, B.V. Subba,Reddy, S. Madhu Sudana,Madan, Ch.
experimental part, p. 1432 - 1435 (2011/06/10)
Ketones possessing α-hydrogen undergo smooth thiocyanation with ammonium thiocyanate in the presence of N-bromosuccinimide (NBS) at room temperature in acetonitrile under neutral conditions to produce the corresponding α-ketothiocyanates in excellent yiel
Expedient synthesis of N-substituted 2-aminothiazoles
Schantl, Joachim G.,Lagoja, Irene M.
, p. 1451 - 1462 (2007/10/03)
The reaction of α-halo ketones 1 with potassium thiocyanate and amines 3 offers the advantage of an efficient one-pot synthesis of the title compounds 4 from readily available starting materials.
