57320-20-4

Basic information

• Product Name: 1H-Benzimidazole-2-acetonitrile,5,6-dimethyl-(9CI)
• Synonyms: 1H-Benzimidazole-2-acetonitrile,5,6-dimethyl-(9CI)
• CAS NO: 57320-20-4
• Molecular Formula: C₁₁H₁₁N₃
• Molecular Weight: 185.22514
• Product Categories: BENZIMIDAZOLE
• Mol File: 57320-20-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole-2-acetonitrile,5,6-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-2-acetonitrile,5,6-dimethyl-(9CI)(57320-20-4)
• EPA Substance Registry System: 1H-Benzimidazole-2-acetonitrile,5,6-dimethyl-(9CI)(57320-20-4)

Safety Data

• Hazardous Substances Data: 57320-20-4(Hazardous Substances Data)

Upstream product

• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 105-34-0 methyl 2-cyanoacetate 
• 105-56-6 ethyl 2-cyanoacetate 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 119750-30-0 3-Hydroxy-7,8-dimethyl-1-oxo-2-phenyl-1,5-dihydro-benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 
• 2148-86-9 ethyl 5,6-dimethyl-1H-benzimidazole-2-acetate 
• 230639-00-6 7,8-dimethyl-1-oxo-1H,5H-3-phenylpyrido<1,2-a>benzimidazole-4-carbonitrile 
• 230639-10-8 1-chloro-7,8-dimethyl-3-phenylpyrido<1,2-a>benzimidazole-4-carbonitrile 
• 230639-09-5 4-cyano-7,8-dimethyl-1-oxo-1H,5H-3-phenylpyrido<1,2-a>benzimidazole-2-carboxaldehyde 
• 119750-53-7 1,3-Dichloro-7,8-dimethyl-2-phenyl-benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 
• 119750-43-5 3-Methoxy-5,7,8-trimethyl-1-oxo-2-phenyl-1,5-dihydro-benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 
• 119750-36-6 3-Hydroxy-7,8-dimethyl-1-oxo-2-phenyl-1,5-dihydro-benzo[4,5]imidazo[1,2-a]pyridine-4-carboxylic acid ethyl ester 
• 119750-57-1 1,3-Dichloro-7,8-dimethyl-2-phenyl-benzo[4,5]imidazo[1,2-a]pyridine-4-carboxylic acid ethyl ester 
• 119750-44-6 3-Ethoxy-5-ethyl-7,8-dimethyl-1-oxo-2-phenyl-1,5-dihydro-benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 
• 119750-35-5 2-Benzyl-3-hydroxy-7,8-dimethyl-1-oxo-1,5-dihydro-benzo[4,5]imidazo[1,2-a]pyridine-4-carboxylic acid ethyl ester 

Relevant articles and documents

Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection

Butyrylcholinesterase (BChE) has been considered as a potential therapeutic target for Alzheimer's disease (AD) because of its compensation capacity to hydrolyze acetylcholine (ACh) and its close association with Aβ deposit. Here, we identified S06-1011 (hBChE IC50 = 16 nM) and S06-1031 (hBChE IC50 = 25 nM) as highly effective and selective BChE inhibitors, which were proved to be safe and long-acting. Candidate compounds exhibited neuroprotective effects and the ability to improve cognition in scopolamine- and Aβ1-42 peptide-induced cognitive deficit models. The best candidate S06-1011 increased the level of ghrelin, a substrate of BChE, which can function as improving the mental mood appetite. The weight gain of the S06-1011-treated group remarkably increased. Hence, BChE inhibition not only plays a protective role against dementia but also exerts a great effect on treating and nursing care.

Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping

We describe a medicinal chemistry approach to generate a series of benzimidazoles bearing thiazolidin-4-one using scaffold hopping from thiazole 1, our previously described thiazole. Our goal was to discover a potent and permeable small-molecule ADAMTS-5 inhibitor. The results suggest that small compound 22 shows promise as a potent small-molecule ADAMTS-5 inhibitor with good permeability.

Synthesis, characterization of some benzazoles bearing pyridine moiety: Search for novel anticancer agents

Thirteen novel benzazole derivatives were synthesized as possible anticancer agents. The first intermediate 1,3-benzothiazol-2-ylacetonitrile (2) was synthesized via cyclodeamination reaction of o-aminothiophenol (1) with malononitrile. Also, the second i