57320-63-5 Usage
General Description
4-(Difluoromethoxy)benzoyl chloride is a chemical compound with the molecular formula C8H5ClF2O2. It is a benzoyl chloride derivative with a difluoromethoxy group attached to the 4-position of the benzene ring. 4-(Difluoromethoxy)benzoyl chloride is commonly used in organic synthesis as a reagent for the introduction of the difluoromethoxy group into various organic molecules. It is a versatile building block in the pharmaceutical and agrochemical industries, and its unique properties make it valuable for the development of new drugs and agricultural chemicals. 4-(Difluoromethoxy)benzoyl chloride is also a useful intermediate for the synthesis of fluorinated organic compounds, which are of interest in medicinal chemistry and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 57320-63-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,2 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 57320-63:
(7*5)+(6*7)+(5*3)+(4*2)+(3*0)+(2*6)+(1*3)=115
115 % 10 = 5
So 57320-63-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClF2O2/c9-7(12)5-1-3-6(4-2-5)13-8(10)11/h1-4,8H
57320-63-5Relevant articles and documents
A preparation method of roflumilast
-
Paragraph 0102-0103; 0108-0109; 0114-0115; 0120-0121, (2019/04/13)
The invention discloses a method for preparation of roflumilast, comprises the following steps: 4 - (methoxy) benzoic acid chlorization reaction to obtain 4 - (methoxy) benzoyl chloride; with 3, 5 - dichloro - 4 - aminopyridine by amidation reaction to obtain N - (3, 5 - dichloro - 4 - pyridyl) - 4 - (methoxy) benzamide; then by Vismeier reaction to obtain N - (3, 5 - dichloro - 4 - pyridyl) - 4 - (methoxy) - 3 - formyl-benzoyl; through the Baeyer - villiger - hydrolysis reaction to obtain N - (3, 5 - dichloro - 4 - pyridyl) - 4 - (methoxy) - 3 - hydroxy benzoyl; then with the [...] yl cyclopropane ether to obtain roflumilast. The invention starting raw material is cheap, the reaction conditions are mild and controllable, synthetic route green environmental protection, high yield, the prepared Roflumilast purity is good.
NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS
-
Page/Page column 33, (2015/04/22)
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
