57322-50-6 Usage
Description
N-ETHYL-N-(4-PICOLYL)ATROPAMIDE is a chemical compound that serves as a significant impurity in Tropicamide (T892650), a medication primarily utilized for the dilation of the pupil. N-ETHYL-N-(4-PICOLYL)ATROPAMIDE is characterized by its structural composition and its association with the pharmaceutical industry due to its presence in a widely used ophthalmic drug.
Uses
Used in Pharmaceutical Industry:
N-ETHYL-N-(4-PICOLYL)ATROPAMIDE is used as an impurity in the formulation of Tropicamide, which is a medication designed for ophthalmic purposes. The application reason for this compound lies in its presence in the synthesis process of Tropicamide, which is employed to dilate the pupil during eye examinations or surgeries. This dilation facilitates a more comprehensive inspection of the eye's interior structures, enabling better diagnosis and treatment of various ocular conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 57322-50-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,2 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 57322-50:
(7*5)+(6*7)+(5*3)+(4*2)+(3*2)+(2*5)+(1*0)=116
116 % 10 = 6
So 57322-50-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H18N2O/c1-3-19(13-15-9-11-18-12-10-15)17(20)14(2)16-7-5-4-6-8-16/h4-12H,2-3,13H2,1H3
57322-50-6Relevant articles and documents
Synthesis of N-picolylcarboxamides via palladium-catalysed aminocarbonylation of iodobenzene and iodoalkenes
Gergely, Máté,Farkas, Roland,Takács, Attila,Petz, Andrea,Kollár, László
, p. 218 - 224 (2014/01/06)
A systematic investigation of the palladium-catalysed aminocarbonylation of iodobenzene, 1-iodocyclohexene and 1′-iodostyrene in the presence of N-nucleophiles containing pyridyl moieties (2-, 3- and 4-picolylamine, N-ethyl-4-picolylamine, di-(2-picolyl)amine) was carried out. The two types of iodo substrates differ substantially regarding the selectivity towards carbonylation: while the aminocarbonylation of iodobenzene resulted in the formation of carboxamide and ketocarboxamide mixtures under various conditions, with the predominant formation of ketocarboxamide even at low carbon monoxide pressure, the aminocarbonylation of iodoalkenes under same conditions gave the corresponding unsaturated carboxamide exclusively. Most of the carboxamides and phenylglyoxylamides, obtained via single and double carbon monoxide insertion, respectively, were isolated in yields of synthetic interest (up to 86%). Low reaction rates and unexpected chemoselectivity towards carboxamide formation have been observed with di-(2-picolyl)amine as N-nucleophile in the aminocarbonylation of iodobenzene.