57327-73-8

Basic information

• Product Name: N-(o-tolyl)benzimidamide
• Synonyms: N-(o-tolyl)benzimidamide
• CAS NO: 57327-73-8
• Molecular Weight: 210.279
• Mol File: 57327-73-8.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: N-(o-tolyl)benzimidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(o-tolyl)benzimidamide(57327-73-8)
• EPA Substance Registry System: N-(o-tolyl)benzimidamide(57327-73-8)

Safety Data

• Hazardous Substances Data: 57327-73-8(Hazardous Substances Data)

Upstream product

• 100-47-0 benzonitrile 
• 95-53-4 o-toluidine 
• 16419-60-6 2-Methylphenylboronic acid 
• 618-39-3 benzamidin 
• 55-21-0 benzamide 
• 615-37-2 ortho-methylphenyl iodide 
• 1670-14-0 benzamidine monohydrochloride 
• 71-43-2 benzene 
• 88-72-2 1-methyl-2-nitrobenzene 
• 14212-87-4 1,1-bis(N-morpholinyl)ethylene 
• 65033-69-4 N-chloro-N'-(2-methylphenyl)benzamidine 

Downstream Products

• 106910-91-2 8-methyl-2,4-diphenylquinazoline 
• 89069-82-9 3-(2-methylphenyl)-2,6-diphenyl-4(3H)-pyrimidinone 
• 89069-66-9 3-(2-methylphenyl)-2-phenyl-4(3H)-pyrimidinone 
• 82635-81-2 2-{[(N¹-o-Tolyl-benzimidoyl)-amino]-methylene}-malonic acid diethyl ester 
• 85615-98-1 5-methyl-1,3-diphenyl-1λ⁴,2,4-benzothiadiazine 
• 3659-77-6 4-methyl-2-phenyl-1H-benzimidazole 
• 85632-70-8 5-methyl-1,3-diphenyl-1λ⁴,2,4-benzoselenadiazine 
• 85739-25-9 N--S-morpholino-S-phenylsulphimide 
• 85616-00-8 5-methyl-1-(4-methylphenyl)-3-phenyl-1λ⁴,2,4-benzothiadiazine 
• 420831-69-2 2-phenyl-N-(o-tolyl)quinazolin-4-amine 
• 1428380-86-2 2,4-diphenyl-1-(o-tolyl)-1H-imidazole 

Relevant articles and documents

Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites

A selective mono-N-arylation strategy of amidines under Chan-Lam conditions is described. During the reaction optimization phase, the isolation of a mononuclear Cu(II) complex provided unique mechanistic insight into the operation of Chan-Lam mono-N-arylation. The scope of the process is demonstrated, and then applied to access the first mono-N-arylated analogues of pentamidine. Sub-micromolar activity against kinetoplastid parasites was observed for several analogues with no cross-resistance in pentamidine and diminazene-resistant trypanosome strains and against Leishmania mexicana. A fluorescent mono-N-arylated pentamidine analogue revealed rapid cellular uptake, accumulating in parasite nuclei and the kinetoplasts. The DNA binding capability of the mono-N-arylated pentamidine series was confirmed by UV-melt measurements using AT-rich DNA. This work highlights the potential to use Chan-Lam mono-N-arylation to develop therapeutic leads against diamidine-resistant trypanosomiasis and leishmaniasis.

Acid-catalyzed synthesis of imidazole derivatives via N-phenylbenzimidamides and sulfoxonium ylides cyclization

A straightforward method to synthesize imidazole derivatives from amidines and sulfoxonium ylides catalyzed by acids is reported in this study. Specifically, catalyzed by trifluoroacetic acid in DCE solvents can improve synthesis efficiency under metal-fr

Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with α-Cl Ketones

In the present study, a novel synthetic strategy to directly produce versatile 3-acylindoles through Rh(III)-catalyzed C-H activation and annulation cascade of N-phenylamidines with α-Cl ketones was developed, in which α-Cl ketones serve as unusual one-carbon (sp3) synthons. This strategy features high regioselectivity, efficiency, wide substrate tolerance, and mild reaction conditions, which further underscore its synthetic utility in drug molecule synthesis.