57334-36-8 Usage
Description
4-CHLORO-8-HYDROXYQUINOLINE is an organic compound characterized by its light green solid appearance. It is a derivative of quinoline, a nitrogen-containing aromatic compound, with a chlorine atom at the 4th position and a hydroxyl group at the 8th position. 4-CHLORO-8-HYDROXYQUINOLINE exhibits unique chemical properties that make it suitable for various applications across different industries.
Uses
Used in Pharmaceutical Industry:
4-CHLORO-8-HYDROXYQUINOLINE is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, particularly those targeting fungal infections.
Used in Antifungal Applications:
4-CHLORO-8-HYDROXYQUINOLINE is used as an antifungal agent for its activity against various fungal species, including Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, and Trichophyton mentagrophytes. Its effectiveness in inhibiting the growth of these fungi makes it a valuable asset in the development of antifungal treatments.
Used in Chemical Synthesis:
4-CHLORO-8-HYDROXYQUINOLINE is used as a building block in the synthesis of other organic compounds. Its versatile structure allows it to be a starting material for the creation of various chemical products, including dyes, pigments, and other specialty chemicals.
Used in Research and Development:
4-CHLORO-8-HYDROXYQUINOLINE is used as a research compound in the field of organic chemistry. Its unique properties make it an interesting subject for studying reaction mechanisms, exploring new synthetic routes, and understanding the relationship between chemical structure and biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 57334-36-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,3 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57334-36:
(7*5)+(6*7)+(5*3)+(4*3)+(3*4)+(2*3)+(1*6)=128
128 % 10 = 8
So 57334-36-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H6ClNO/c10-7-4-5-11-9-6(7)2-1-3-8(9)12/h1-5,12H
57334-36-8Relevant articles and documents
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
Thinnes,Tumber,Yapp,Scozzafava,Yeh,Chan,Tran,Hsu,Tarhonskaya,Walport,Wilkins,Martinez,Müller,Pugh,Ratcliffe,Brennan,Kawamura,Schofield
, p. 15458 - 15461 (2015/10/20)
There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. The 3-component Betti reaction enables efficient one-step C-7 functionalisation of modified 8-hydroxyquinolines (8HQs) to produce cell-active inhibitors of KDM4 histone demethylases and other 2OG oxygenases; the work exemplifies how a template-based metallo-enzyme inhibitor approach can be used to give biologically active compounds.
Synthesis of 4-[4-(N,N-dimethylsulfamoyl)piperazin-1-yl]-quinolines derivatives as sorbitol dehydrogenase potential inhibitors
Varlet, Didier,Fourmaintraux, Eric,Depreux, Patrick,Lesieur, Daniel
, p. 385 - 396 (2007/10/03)
Synthesis of various quinolines, substituted in position 4 by [4-(N,N-dimethylsulfamoyl)piperazin-1-yl] group and in position 2 by different groups such as hydrogen, methyl, hydroxymethyl, formyl or carboxyl is described. Besides, we have synthesized derivatives of 8-hydroxyquinoline.
Improved Syntheses of Some Monohloro- and Monobromo-8-quinolinols
Gershon, Herman,Clarke, Donald D.
, p. 935 - 942 (2007/10/02)
Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz 1H-NMR spetra for the 12 possible monochloro
