57339-90-9

Basic information

• Product Name: C₁₉H₁₄O₆
• Synonyms: C₁₉H₁₄O₆
• CAS NO: 57339-90-9
• Molecular Weight: 338.317
• Mol File: 57339-90-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₄O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₄O₆(57339-90-9)
• EPA Substance Registry System: C₁₉H₁₄O₆(57339-90-9)

Safety Data

• Hazardous Substances Data: 57339-90-9(Hazardous Substances Data)

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 2555-37-5 3-acetyl-4-hydroxychromen-2-one 
• 121-33-5 vanillin 
• 138769-50-3 trans-4-hydroxy-3-methoxycinnamic acid chloride 
• 326925-91-1 3-acetyl-chroman-2,4-dione 

Relevant articles and documents

Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities

A simple synthesis and biological properties of 1,3-diphenyl-2-propen-1-ones 18-22 and 25-26 are described. The key synthetic strategies involve Grignard reaction of aldehyde 2 and oxidation reaction of 8-12 in high yields. The prepared compounds 18-22 an

Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents

A novel series of 3-cinnamoyl-4-hydroxy-2Hchromen-2-ones were designed, synthesized and screened for antiplasmodial activity. Eleven compounds of the series exhibited micromolar potency against chloroquine sensitive and chloroquine resistant strains. The most potent compound 4-hydroxy-3-(3-(4- nitrophenyl)acryloyl)-2Hchromen-2-one showed inhibitory potency (IC 50) of 3.1 and 4 μg/ml against chloroquine sensitive and chloroquine resistant strains, respectively. A structure activity relationship study was performed by correlating the effect of substituents with the antimalarial activity of the title compounds. The novel 3-cinnamoyl-4-hydroxy- 2H-chromen-2-ones reported here should be good lead for further development of antimalarial agents that can overcome resistance.