57342-29-7

Basic information

• Product Name: 1-(p-tolylsulfonyloxy)oct-2-yne
• Synonyms: 1-(p-tolylsulfonyloxy)oct-2-yne
• CAS NO: 57342-29-7
• Molecular Weight: 280.388
• Mol File: 57342-29-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(p-tolylsulfonyloxy)oct-2-yne(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(p-tolylsulfonyloxy)oct-2-yne(57342-29-7)
• EPA Substance Registry System: 1-(p-tolylsulfonyloxy)oct-2-yne(57342-29-7)

Safety Data

• Hazardous Substances Data: 57342-29-7(Hazardous Substances Data)

Upstream product

• 628-71-7 1-Heptyne 
• 111-12-6 methyl 2-octynoate 
• 5663-96-7 oct-2-ynoic acid 

Downstream Products

• 28290-73-5 (7Z,10Z)-7,10-hexadecadienoic acid 
• 18829-90-8 (7Z,10Z)-hexadecadienoic acid methyl ester 
• 39039-37-7 (5Z,8Z)-tetradecadienoic acid 
• 1041848-36-5 [NMe₂(2-octynyl)(CH=C(CH₃)2)][OTS] 
• 265331-22-4 N-(p-tolylsulfonyl) undeca-4,5-dienylamine 
• 18495-27-7 1-bromooct-2-yne 
• 62055-70-3 methyl-4 pentyl-3 pentatriene-1,2,4 

Relevant articles and documents

Synthesis of deuterated γ-linolenic acid and application for biological studies: Metabolic tuning and Raman imaging

γ-Linolenic acid (GLA) is reported to show tumor-selective cytotoxicity through unidentified mechanisms. Here, to assess the involvement of oxidized metabolites of GLA, we synthesized several deuterated GLAs and evaluated their metabolism and cytotoxicity towards normal human fibroblast WI-38 cells and VA-13 tumor cells generated from WI-38 by transformation with SV40 virus. Deuteration of GLA suppressed both metabolism and cytotoxicity towards WI-38 cells and increased the selectivity for VA-13 cells. Fully deuterated GLA was visualized by Raman imaging, which indicated that GLA is accumulated in intracellular lipid droplets of VA-13 cells. Our results suggest the tumor-selective cytotoxicity is due to GLA itself, not its oxidized metabolites. This journal is