57346-40-4

Basic information

• Product Name: diethyl 2-hydroxy-2-(2-oxocyclohexyl)propanedioate
• Synonyms: diethyl 2-hydroxy-2-(2-oxocyclohexyl)propanedioate
• CAS NO: 57346-40-4
• Molecular Weight: 272.298
• Mol File: 57346-40-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: diethyl 2-hydroxy-2-(2-oxocyclohexyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-hydroxy-2-(2-oxocyclohexyl)propanedioate(57346-40-4)
• EPA Substance Registry System: diethyl 2-hydroxy-2-(2-oxocyclohexyl)propanedioate(57346-40-4)

Safety Data

• Hazardous Substances Data: 57346-40-4(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 609-09-6 Diethyl ketomalonate 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 

Downstream Products

• 1026695-75-9 diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate 
• 459167-87-4 diethyl 2-[3,3-bis(phenylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate 
• 57631-27-3 diethyl 2-(6-oxocyclohex-1-enyl)malonate 
• 208401-68-7 diethyl 2-acetoxy-2-(2-oxocyclohexyl)malonate 
• 93783-98-3 hydroxy-(2-oxo-cyclohexyl)-malonic acid 

Relevant articles and documents

Enantioselective mukaiyama-aldol reaction between enol silanes and ketomalonate catalyzed by the copper(II) complex of tips-substituted bis-oxazoline

The stable complex [(4'S,5'S)-4b/Cu(Tf)2/H2O] (5), obtained from TIPS-Box and Copper triflate, catalyzes enantioselectively the Mukaiyama-aldol reactions between two silyl enol ethers (1a,b) and diethyl ketomalonate (2). Yields are v

METALLOENZYME INHIBITOR COMPOUNDS

Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Synthesis of the bicyclo[4.3.1]decenone core of CP-225,917 and CP-263,114

The bicyclo[4.3.1]decenone core of the ras-farnesyl protein transferee inhibitors CP-225,917 and CP-263,114 is prepared in 6 steps from cyclohexanone. The key step is an intramolecular Mukaiyama aldol reaction.