57356-28-2

Basic information

• Product Name: 5-NITRO-2,3-DIHYDRO-1,4-BENZODIOXINE
• Synonyms: 5-NITRO-2,3-DIHYDRO-1,4-BENZODIOXINE;5-Nitro-2,3-dihydrobenzo[b][1,4]dioxine
• CAS NO: 57356-28-2
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.15
• Product Categories: Benzodiozoles, Benzodioxines & Benzodioxepines
• Mol File: 57356-28-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287.968°C at 760 mmHg
• Flash Point: 143.662°C
• Appearance: /
• Density: 1.391g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 5-NITRO-2,3-DIHYDRO-1,4-BENZODIOXINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-2,3-DIHYDRO-1,4-BENZODIOXINE(57356-28-2)
• EPA Substance Registry System: 5-NITRO-2,3-DIHYDRO-1,4-BENZODIOXINE(57356-28-2)

Safety Data

• Hazardous Substances Data: 57356-28-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7NO4/c10-9(11)6-2-1-3-7-8(6)13-5-4-12-7/h1-3H,4-5H2

Upstream product

• 493-09-4 benzo-1,4-dioxane 
• 6665-98-1 3-nitrobenzene-1,2-diol 
• 106-93-4 ethylene dibromide 
• 1643-19-2 tetrabutylammomium bromide 

Downstream Products

• 59820-94-9 5,6-dinitro-2,3-dihydrobenzo[b][1,4]dioxine 
• 59820-95-0 5,7-dinitro-2,3-dihydro-benzo[1,4]dioxine 
• 16081-45-1 1,4-benzodioxan-5-amine 

Relevant articles and documents

2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS

The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.

N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides

Piperazine derivatives of formula I and their pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists and may be used, for example, as anxiolytics. In the formula A is C2-4 alkylene chain optionally substituted by lower alkyl, Z is oxygen or sulphur, R is hydrogen or lower alkyl, R1 is a mono or bicyclic aryl or heteroaryl radical, R2 is a mono or bicyclic heteroaryl radical and R3 is hydrogen or a specified radical such as lower alkyl, cycloalkyl, aryl, heteroaryl or optionally substituted amino.

Influence of the Heterocyclic Side Ring on Orientation During Nitrations of 1,2-Alkylenedioxy-annelated Benzenes and Their Mononitro Derivatives

Nitration of 1,2-alkylenedioxybenzenes 1 furnished the respective nitro derivatives 3 and 4 in the relative ratios: 4a:3a/100:trace, 4b:3b/98:2.4, 4c:3c/86:14, 4e:3e/91:9, 4f:3f/99:1.3.Nitration of 4 gave 5a:6a:8a/0:0:100, 5b:6b:8b/7.7:3.2:89, 5c:6c:8c/23:12:65, 5d:6d:8d/14:74:12, 5e:6e:8e/27:18:55 and 5f:6f:8f/23:7.0:70.Nitration of the isomeric 3 afforded the dinitroproducts 5, 6 and 7 in the following relative ratios: 5a:6a:7a/92:8:0, 5b:6b:7b/80:20:0, 5c:6c:7c/69:20:11, 5d:6d:7d/45:19:36, 5e:6e:7e/37:57:5.9 and 5f:6f:7f/64:36:0.Nitration of 3-nitro-1,2-dimethoxybenzene (9) furnished: 10:11/63:37.Orientation as a function of the h eterocyclic ring-size is discussed.