5736-06-1

Basic information

• Product Name: 2,2-DiMethyl-1,3-dioxolane-4-carboxylic acid
• Synonyms: (rec.) 2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid
• CAS NO: 5736-06-1
• Molecular Formula: C₆H₁₀O₄
• Molecular Weight: 146.1412
• Mol File: 5736-06-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 68 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 244.2±35.0 °C(Predicted)
• Appearance: White solid
• Density: 1.203±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.12±0.40(Predicted)
• CAS DataBase Reference: 2,2-DiMethyl-1,3-dioxolane-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DiMethyl-1,3-dioxolane-4-carboxylic acid(5736-06-1)
• EPA Substance Registry System: 2,2-DiMethyl-1,3-dioxolane-4-carboxylic acid(5736-06-1)

Safety Data

• Hazardous Substances Data: 5736-06-1(Hazardous Substances Data)

Usage

General Description

2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid, also known as DMCOOH, is a chemical compound with a molecular formula C7H12O4. It is a synthetic intermediate used in the production of pharmaceuticals and agrochemicals. DMCOOH is a white to off-white crystalline solid with a melting point of 95-100°C and is sparingly soluble in water. It is primarily used as a building block in the synthesis of various drugs and has applications in the field of medicinal chemistry. However, it is important to handle this compound with precaution as it is a potential irritant and can cause skin and eye irritation upon contact.

Upstream product

• 108865-84-5 methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 134036-81-0 (4S,5S)-5-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid anion 
• 14131-84-1 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose 
• 7306-64-1 2,3,5,6-di-O-isopropylidene-D-mannono-1,4-lactone 
• 5736-03-8 (d,l) isopropylidene glyceraldehyde 

Downstream Products

• 108865-84-5 methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 1026631-82-2 4-(1-Hydroxy-2-phenylselanyl-ethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 158091-91-9 C₁₇H₂₃NO₄ 
• 90493-96-2 2,2-dimethyl-1,3-dioxolane-4-carboxylic acid chloride 

Relevant articles and documents

Synthesis of phospholipids on a glyceric acid scaffold: Design and preparation of phospholipase A2 specific substrates

Synthesis of a new series of phospholipid analogues to serve as activity-based probes of secretory phospholipase A2 enzymes is reported. The synthesis is based upon (1) preparation of long-chain esters and amides of glyceric acid, followed by (

Electrochemical Oxidation of Alcohols and Aldehydes to Carboxylic Acids Catalyzed by 4-Acetamido-TEMPO: An Alternative to "anelli" and "pinnick" Oxidations

An electrocatalytic method has been developed to oxidize primary alcohols and aldehydes to the corresponding carboxylic acids using 4-acetamido-2,2,6,6-tetramethylpiperidin-1-oxyl (ACT) as a mediator. The method successfully converts benzylic, aliphatic, heterocyclic, and other heteroatom-containing substrates to the corresponding carboxylic acids in aqueous solution at room temperature. The mild conditions enable retention of stereochemistry adjacent to the site of oxidation, as demonstrated in a 40 g-scale synthesis of a precursor to levetiracetam, a medication used to treat epilepsy.

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.