5736-70-9Relevant articles and documents
Pd-Catalyzed C?H Alkylation of Arenes Using PyrDipSi, a Transformable and Removable Silicon-Tethered Directing Group
Sarkar, Dhruba,Gevorgyan, Vladimir
, p. 11201 - 11204 (2016/08/03)
An efficient Pd-catalyzed ortho-C?H alkylation reaction of arenes using a transformable and removable Si-tethered pyridyldiisopropylsilyl (PyrDipSi) directing group has been developed. In addition, the PyrDipSi directing group allows for an efficient sequential double-fold C?H alkylation/oxygenation of arenes to produce meta-alkylated phenols. This directing group can easily be removed or converted into valuable functionalities, such as aryl, iodo, boronic ester, or phenol.