57362-82-0

Basic information

• Product Name: 1H-1,2,3-Triazole-4-carboxylicacid,1-methyl-,methylester(9CI)
• Synonyms: 1H-1,2,3-Triazole-4-carboxylicacid,1-methyl-,methylester(9CI);Methyl 1-Methyl-1,2,3-triazole-4-carboxylate;Methyl 1-methyl-1H-1,2,3-triazole-4-carboxylate;1-methyl-1H-1,2,3-Triazole-4-carboxylic acid methyl ester
• CAS NO: 57362-82-0
• Molecular Formula: C5H7N3O2
• Molecular Weight: 141.13
• Product Categories: CARBOXYLICESTER
• Mol File: 57362-82-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 246.089°C at 760 mmHg
• Flash Point: 102.632°C
• Appearance: /
• Density: 1.324g/cm³
• Vapor Pressure: 0.028mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 1H-1,2,3-Triazole-4-carboxylicacid,1-methyl-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,3-Triazole-4-carboxylicacid,1-methyl-,methylester(9CI)(57362-82-0)
• EPA Substance Registry System: 1H-1,2,3-Triazole-4-carboxylicacid,1-methyl-,methylester(9CI)(57362-82-0)

Safety Data

• Hazardous Substances Data: 57362-82-0(Hazardous Substances Data)

Usage

General Description

1H-1,2,3-Triazole-4-carboxylic acid, 1-methyl-, methyl ester (9CI) is a chemical compound with the molecular formula C6H7N3O2. It is a methyl ester derivative of 1H-1,2,3-triazole-4-carboxylic acid, and is commonly used in the synthesis of pharmaceuticals and other organic compounds. 1H-1,2,3-Triazole-4-carboxylicacid,1-methyl-,methylester(9CI) exhibits a variety of biological activities, including antifungal, antibacterial, and antiviral properties. It is also used as a building block in the production of various agrochemicals and insecticides. Additionally, 1H-1,2,3-Triazole-4-carboxylic acid, 1-methyl-, methyl ester (9CI) has been utilized in the development of potential anticancer agents and other medicinal compounds. Overall, this chemical plays an important role in the pharmaceutical and agrochemical industries due to its versatile applications and biological activities.

InChI:InChI=1/C5H7N3O2/c1-8-3-4(6-7-8)5(9)10-2/h3H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 17640-15-2 methyl cyanoformate 
• 35234-87-8 dimethyl 2,3-dicyanofumarate 
• 24153-51-3 diazomethane 
• 105020-40-4 trans-4,5-Dicyan-4,5-dihydro-1H-pyrazol-4,5-dicarbonsaeure-dimethylester 
• 73499-98-6 5-cyano-1-methyl-1,5-dihydro-[1,2,3]triazole-4,4-dicarboxylic acid dimethyl ester 
• 52745-92-3 methyl (E)-3-nitroacrylate 
• 624-90-8 methyl azide 
• 922-67-8 propynoic acid methyl ester 
• 4967-77-5 methyl 1,2,3-triazole-4-carboxylate 
• 74-88-4 methyl iodide 

Relevant articles and documents

Some Aspects of the Azide-Alkyne 1,3-Dipolar Cycloaddition Reaction

Some peculiar features of two most commonly used catalytic systems (Cul and CuSOVsodium ascorbate) controlling the regioselectivity of 1,3-dipolar cycloaddition of azides to terminal alkynes have been studied. Their potentialities, main disadvantages, and limitations have been demonstrated by a number of examples, including reactions of low-molecular-weight azides and alkynes containing heterocyclic substituents. The possibility of using novel reagents in click reactions is discussed.

Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers

Nonselective inverse agonists at the γ-aminobutyric acidA (GABA-A) benzodiazepine binding site have cognition-enhancing effects in animals but are anxiogenic and can precipitate convulsions. Herein, we describe novel GABA-A α5 subtype inverse agonists leading to the identification of 16 as an orally active, functionally selective compound that enhances cognition in animals without anxiogenic or convulsant effects. Compounds of this type may be useful in the symptomatic treatment of memory impairment associated with Alzheimer's disease and related dementias.

1,3-Dipolar Cycloadditions, 93. - The Astounding Reaction of Dimethyl 2,3-Dicyanofumarate with Diazomethane

The reaction with excess of diazomethane furnished methyl 4-cyano-1-methylpyrazole-5- and -3-carboxylate (2 and 3) as well as the three N-methyl-1,2,3-triazolecarboxylic esters 4-6.A mechanistic study revealed a poly-step sequence.The initial formation of the pyrazoline 8 proceeded normal.Base catalysis effected an equilibration of trans- and cis-2-pyrazoline, 8(*)12, followed by a fragmentation into methyl 4-cyano-3-pyrazolecarboxylate (26) and methyl cyanoformate (32); a 4H-pyrazole is supposed to be the key intermediate.The final products mentioned above emerged from further reaction of 26 and 32 with diazomethane.