573658-88-5

Basic information

• Product Name: Cyclobutanecarboxylic acid, 1-[[(3S,4R)-3-(3-fluorophenyl)-4-formyl-1-pyrrolidinyl]methyl]-, phenylmethyl ester
• CAS NO: 573658-88-5
• Molecular Formula: C24H26FNO3
• Molecular Weight: 395.474
• Mol File: 573658-88-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclobutanecarboxylic acid, 1-[[(3S,4R)-3-(3-fluorophenyl)-4-formyl-1-pyrrolidinyl]methyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanecarboxylic acid, 1-[[(3S,4R)-3-(3-fluorophenyl)-4-formyl-1-pyrrolidinyl]methyl]-, phenylmethyl ester(573658-88-5)
• EPA Substance Registry System: Cyclobutanecarboxylic acid, 1-[[(3S,4R)-3-(3-fluorophenyl)-4-formyl-1-pyrrolidinyl]methyl]-, phenylmethyl ester(573658-88-5)

Safety Data

• Hazardous Substances Data: 573658-88-5(Hazardous Substances Data)

Upstream product

• 573659-00-4 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester 
• 419571-31-6 dibenzyl cyclobutane-1,1-dicarboxylate 
• 301184-91-8 3-(R)-(tert-butyldimethylsilyloxymethyl)-4-(S)-(3-fluoro)phenylpyrrolidine 
• 419571-30-5 benzyl 1-formylcyclobutanecarboxylate 
• 5445-51-2 cyclobutane-1,1'-dicarboxylic acid 
• 573659-04-8 1-[(3S,4R)-3-(3-Fluoro-phenyl)-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester 

Downstream Products

• 573658-93-2 1-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclobutanecarboxylic acid benzyl ester 

Relevant articles and documents

CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity

(Matrix presented) A novel approach to α,α-disubstituted-β -amino acids (β2,2-amino acids) was employed in the synthesis of a series of 3-(pyrrolidin-1-yl)-propionic acids possessing high affinity for the CCR5 receptor and potent anti-HIV activity. The rat pharmacokinetics for these new analogues featured higher bioavailabilities and lower rates of clearance as compared to cyclopentane 1.