573675-27-1

Basic information

• Product Name: 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE
• Synonyms: 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE;3-Amino-5-bromopicolinonitrile
• CAS NO: 573675-27-1
• Molecular Formula: C₆H₄BrN₃
• Molecular Weight: 198.02006
• Mol File: 573675-27-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 376.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.80±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -1.28±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE(573675-27-1)
• EPA Substance Registry System: 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE(573675-27-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 573675-27-1(Hazardous Substances Data)

Usage

General Description

3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE is a chemical compound with the molecular formula C6H4BrN3. It is a nitrile derivative of pyridine and is comprised of a pyridine ring with an amino group at the 3-position, a bromine atom at the 5-position, and a nitrile group at the 2-position. 3-AMINO-5-BROMO-PYRIDINE-2-CARBONITRILE is commonly used in organic synthesis and medicinal chemistry for the development of pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a versatile building block for the synthesis of various nitrogen-containing heterocycles and biologically active compounds. Additionally, its properties make it an important intermediate in the production of numerous valuable compounds for various industrial applications.

Upstream product

• 90902-84-4 2,5-dibromopyridin-3-ylamine 
• 15862-37-0 2,5-dibromo-3-nitro-pyridine 
• 6945-68-2 5-bromo-3-nitro-pyridin-2-ylamine 
• 15862-34-7 5-bromo-3-nitro-2-pyridone 
• 573675-25-9 5-bromo-3-nitropyridine-2-carbonitrile 

Downstream Products

• 573675-29-3 7-bromopyrido[3,2-d]pyrimidin-4-ol 
• 945557-04-0 5-bromo-3-chloro-pyridine-2-carbonitrile 
• 1112983-01-3 N-(5-bromo-2-cyanopyridin-3-yl)-4-methoxybenzenesulfonamide 
• 1112981-97-1 N-(6-(6-cyano-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide 
• 1297538-79-4 3-chloro-5-(1-((2-tritylamino)ethyl)-1H-pyrazol-3-yl)picolinonitrile 

Relevant articles and documents

Selective inhibitors of cyclin G associated kinase (GAK) as anti-hepatitis C agents

Cyclin G associated kinase (GAK) emerged as a promising drug target for the treatment of viral infections. However, no potent and selective GAK inhibitors have been reported in the literature to date. This paper describes the discovery of isothiazolo[5,4-

A Scaffold-Hopping Strategy toward the Identification of Inhibitors of Cyclin G Associated Kinase

We recently reported the discovery of isothiazolo[4,3-b]pyridine-based inhibitors of cyclin G associated kinase (GAK) displaying low nanomolar binding affinity for GAK and demonstrating broad-spectrum antiviral activity. To come up with novel core structures that act as GAK inhibitors, a scaffold-hopping approach was applied starting from two different isothiazolo[4,3-b]pyridines. In total, 13 novel 5,6- and 6,6-fused bicyclic heteroaromatic scaffolds were synthesized. Four of them displayed GAK affinity with Kd values in the low micromolar range that can serve as chemical starting points for the discovery of GAK inhibitors based on a different scaffold.

GAK MODULATORS AS ANTIVIRALS

The present invention relates to the use of a class of novel isothiazolo[4,3-b]pyridine derivatives as well as to pharmaceutical compositions comprising one or more of said isothiazolo[4,3- b]pyridine derivatives and one or more pharmaceutically acceptable excipients as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as viral diseases.