57381-37-0Relevant articles and documents
Selective synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines via copper-catalyzed tandem annulation of alkynylbenzonitriles with 2-Iodoanilines
Liu, Xiaodong,Deng, Guobo,Liang, Yun
, p. 2844 - 2847 (2018/06/18)
An efficient copper-catalyzed cascade cyclization reaction for selectively synthesizing a variety of benzo[4,5]imidazo[2,1-a]isoquinoline derivatives has been developed. The reaction features the formation of three different C–N bonds in sequence. In the
Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5
Zhang, Peng,Zou, Mu-Fa,Rodriguez, Alice L.,Jeffrey Conn,Newman, Amy Hauck
scheme or table, p. 3026 - 3035 (2010/07/06)
The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in numerous neuropsychiatric disorders including addiction. We have discovered that the rigid diaryl alkyne template, derived from the potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), can serve to guide the design of novel quinoline analogues and pharmacophore optimization has resulted in potent mGluR5 noncompetitive antagonists (EC50 range 60-100 nM) in the quinoline series.
An efficient synthesis of a highly functionalized 4-arylpiperidine
Boice, Geneviève N.,Savarin, Cécile G.,Murry, Jerry A.,Conrad, Karen,Matty, Louis,Corley, Edward G.,Smitrovich, Jacqueline H.,Hughes, Dave
, p. 11367 - 11374 (2007/10/03)
In this manuscript, an efficient synthesis of a functionalized 4-arylpiperidine is disclosed. Several synthetic approaches towards formation of the key aryl-piperidine sp3 carbon-carbon bond are discussed, including a scalable route to the piperidine via
