574-06-1Relevant articles and documents
(2-Fluoroallyl)boration of Ketones with (2-Fluoroallyl)boronates
Novikov, Maxim A.,Bobrova, Angelina Yu.,Mezentsev, Igor A.,Medvedev, Michael G.,Tomilov, Yury V.
, p. 6295 - 6308 (2020)
Efficient routes toward activation of gem-chlorofluorocyclopropane-derived (2-fluoroallyl)boronates for allylboration of various ketones including functionalized and low-reactive ones were developed. Increasing the boron electrophilicity by the transforma
Selective Synthesis of Acylated Cross-Benzoins from Acylals and Aldehydes via N-Heterocyclic Carbene Catalysis
Onodera, Kou,Suzuki, Yumiko,Takashima, Ryo
, p. 4197 - 4202 (2021/06/27)
The utility of acylals as building blocks for selective cross-benzoin synthesis was explored in this study. The synthesis of α-acetoxyketones (O-acyl cross-benzoins) was achieved via selective N-heterocyclic carbene-catalyzed cross-benzoin reactions using acylals as aldehyde equivalents. Thus, the combination of ortho-substituted phenyl acylals and aromatic/aliphatic aldehydes as coupling substrates using bicyclic triazolium salts as precatalysts and potassium carbonate as a base in THF at reflux temperature selectively yielded O-acyl cross-benzoins.
Sulfur-mediated difunctionalization of internal and terminal alkynes for the synthesis of α-acetoxy ketones
Li, Pingfan,Zhang, Zhong
, (2020/02/13)
The sulfur-mediated difunctionalization of alkynes is reported to give α-acetoxy ketones in a one-pot operation under mild conditions with 19–92% yield. By using wet potassium acetate as both the aqueous base and nucleophilic reagent, both terminal alkynes and internal alkynes could be converted into the α-acetoxy ketone products.
