574-77-6

Basic information

• Product Name: papaveroline
• Synonyms: papaveroline;1-(3,4-Dihydroxybenzyl)-6,7-isoquinolinediol;Einecs 209-374-1;Papaverolina;Papaverolina [inn-spanish];Papaverolinum;Papaverolinum [inn-latin];Unii-A0cr5J8X17
• CAS NO: 574-77-6
• Molecular Formula: C16H13NO4
• Molecular Weight: 283.28
• EINECS: 209-374-1
• Mol File: 574-77-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 634°Cat760mmHg
• Flash Point: 337.2°C
• Appearance: /
• Density: 1.52g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.772
• CAS DataBase Reference: papaveroline(CAS DataBase Reference)
• NIST Chemistry Reference: papaveroline(574-77-6)
• EPA Substance Registry System: papaveroline(574-77-6)

Safety Data

• Hazardous Substances Data: 574-77-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H13NO4/c18-13-2-1-9(6-14(13)19)5-12-11-8-16(21)15(20)7-10(11)3-4-17-12/h1-4,6-8,18-21H,5H2

Upstream product

• 58-74-2 Papaverine 

Downstream Products

• 1721-93-3 1-methylisoquinoline 

Relevant articles and documents

Protoberberine Alkaloids and Related Compounds as Dual Inhibitors of Mammalian Topoisomerase I and II

Berberine and several structurally-related analogs were evaluated as inhibitors of topoisomerase I and II. The pharmacological activity of protoberberines exhibited a strong dependence upon the type and location of substituents. Several of these alkaloids exhibited activity as inhibitors of topoisomerase II. Among the bicyclic heterocyclic analogs evaluated, none exhibited similar potency to berberrubine as an inhibitor of topoisomerase II. Of the analogs studied, 2,3-desmethylene-9,10-desmethylberberine was the most potent inhibitor of topoisomerase I when assayed in vitro.