5741-22-0

Basic information

• Product Name: moprolol
• Synonyms: moprolol;DL-MOPROLOL;1-(Isopropylamino)-3-(2-methoxyphenoxy)-2-propanol;[2-Hydroxy-3-(2-methoxyphenoxy)propyl](propan-2-yl)amine
• CAS NO: 5741-22-0
• Molecular Formula: C₁₃H₂₁NO₃
• Molecular Weight: 239.31074
• EINECS: 227-254-7
• Mol File: 5741-22-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 82-83°
• Boiling Point: 379.2°Cat760mmHg
• Flash Point: 183.2°C
• Appearance: /
• Density: 1.054g/cm³
• Vapor Pressure: 1.99E-06mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: moprolol(CAS DataBase Reference)
• NIST Chemistry Reference: moprolol(5741-22-0)
• EPA Substance Registry System: moprolol(5741-22-0)

Safety Data

• Hazardous Substances Data: 5741-22-0(Hazardous Substances Data)

Usage

Description

Moprolol is a medication that belongs to the beta-blocker class of drugs, which are used to treat conditions such as high blood pressure, angina, and heart failure. It works by slowing down the heart rate and reducing the force of the heart's contractions, thereby helping to lower blood pressure and improve the heart's ability to pump blood. Moprolol also has the ability to reduce the workload of the heart, making it a useful medication for individuals with heart conditions. Additionally, it may also be prescribed to prevent migraine headaches and reduce the risk of future heart attacks. Overall, moprolol is an important medication in the management of various cardiovascular and related conditions.

Uses

Used in Cardiovascular Applications:
Moprolol is used as an antihypertensive agent for treating high blood pressure. It helps to lower blood pressure by slowing down the heart rate and reducing the force of the heart's contractions.
Moprolol is used as an antianginal agent for treating angina, a condition characterized by chest pain due to insufficient blood flow to the heart. It reduces the workload of the heart, thereby relieving chest pain and improving the heart's ability to pump blood.
Moprolol is used as a heart failure treatment for managing heart failure, a condition in which the heart is unable to pump blood effectively. It helps to improve the heart's ability to pump blood and reduce the workload on the heart.
Used in Neurological Applications:
Moprolol is used as a migraine prevention medication for preventing migraine headaches. It may help to reduce the frequency and severity of migraines in susceptible individuals.
Used in Secondary Prevention of Cardiovascular Events:
Moprolol is used as a secondary prevention medication for reducing the risk of future heart attacks in individuals who have previously experienced a heart attack. It helps to manage cardiovascular conditions and reduce the likelihood of recurrent events.

InChI:InChI=1/C13H21NO3/c1-10(2)14-8-11(15)9-17-13-7-5-4-6-12(13)16-3/h4-7,10-11,14-15H,8-9H2,1-3H3

Upstream product

• 25772-81-0 1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol 
• 75-31-0 isopropylamine 

Downstream Products

• 101115-94-0 3-isopropyl-5-(2-methoxy-phenoxymethyl)-oxazolidin-2-one 

Related news

Identification and determination of the enantiomers of moprolol (cas 5741-22-0) and their metabolites in human urine by high-performance liquid chromatography and gas chromatography—mass spectrometry07/16/2019

A simple and sensitive high-performance liquid chromatographic (HPLC) method using chiral derivatization was developed to screen and determine the enantiomers of moprolol and their metabolites in human urine. The recovery of (+)- and (−)-moprolol from urine was 70.8–81.1% at different concentra...detailed

Relevant articles and documents

Substrate processing device and method therefor

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ANTIHYPERTENSIVE THERAPY

A new use of darusentan is provided in preparation of a pharmaceutical composition for lowering blood pressure in a patient exhibiting resistance to a baseline antihypertensive therapy with one or more drugs. The composition comprises darusentan in an amount providing a therapeutically effective daily dose; wherein (a) the composition is orally deliverable and/or (b) the daily dose of darusentan is effective to provide a reduction of at least about 3 mmHg in one or more blood pressure parameters selected from trough sitting systolic, trough sitting diastolic, 24-hour ambulatory systolic, 24-hour ambulatory diastolic, maximum diurnal systolic and maximum diurnal diastolic blood pressures. Further provided is a new use of darusentan in preparation of a pharmaceutical composition for lowering blood pressure in a patient exhibiting resistance to a baseline antihypertensive therapy, wherein the composition is administered adjunctively with at least one diuretic and at least one antihypertensive drug selected from ACE inhibitors, angiotensin II receptor blockers, beta-adrenergic receptor blockers and calcium channel blockers.

Laevorotatory antipode of moprolol as an antihypertensive

This invention relates to a process for the separation of moprolol into its two optical antipodes, substantially characterized by the fact of salifying racemic moprolol with L(+)glutamic acid; treating the thus obtained mixture of diastereoisomeric salts with a water/alcohol mixture, in this way separating the L(+)glutamate insoluble salt of (+)moprolol; treating the resultant mother liquors which contain in solution the L(+)glutamate salt of (-)moprolol with a base so as to separate the laevorotatory isomer of crystalline moprolol, which finally undergoes a purification. The invention also relates to a pharmaceutical composition containing said laevorotatoryisomer of moprolol.