57439-16-4

Basic information

• Product Name: methyl 2-hydroxy-6-methoxy-4-methylbenzoate
• Synonyms: methyl 2-hydroxy-6-methoxy-4-methylbenzoate
• CAS NO: 57439-16-4
• Molecular Weight: 196.203
• Mol File: 57439-16-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-hydroxy-6-methoxy-4-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-hydroxy-6-methoxy-4-methylbenzoate(57439-16-4)
• EPA Substance Registry System: methyl 2-hydroxy-6-methoxy-4-methylbenzoate(57439-16-4)

Safety Data

• Hazardous Substances Data: 57439-16-4(Hazardous Substances Data)

Upstream product

• 54130-89-1 2,6-dimethoxy-4-methyl-benzoic acid methyl ester 
• 186581-53-3 diazomethane 
• 16846-10-9 methyl 2,6-dihydroxy-4-methylbenzoate 
• 480-67-1 2,6-dihydroxy-4-methyl-benzoic acid 
• 504-15-4 orcinol 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 4860-88-2 4-hydroxy-7-methyl-2H,5H-pyrano[4,3-b]pyran-2,5-dione 
• 33176-11-3 2,7-dimethyl-4H-pyrano<3,2-c>-2H-pyran-4,5-dione 

Downstream Products

• 114561-50-1 acide hydroxy-2-methoxy-6-methyl-4-benzoique 
• 32743-99-0 3-formyl-2-hydroxy-6-methoxy-4-methyl-benzoic acid methyl ester 
• 205880-83-7 1-(2-Hydroxy-6-methoxy-4-methyl-phenyl)-2-methanesulfinyl-ethanone 

Relevant articles and documents

Design and Synthesis of Structure-Simplified Derivatives of Gonytolide for the Promotion of Innate Immune Responses

Gonytolide A (1), a dimeric chromanone substituted with the-lactone, shows promoting activity of innate immune responses. However, biological studies on this compound have been limited by the low amounts of 1 available from natural resources and the difficulty of its synthesis. In this study, we designed and synthesized structure-simplified gonytolide derivatives. Bischromone 10 and biflavone 13 both promoted the mammalian TNF-α signaling pathway and Drosophila innate immunity. They did not contain a chiral center and were easy to synthesize. Hence, they can be used as lead compounds for a new type of immunostimulating drugs and as research reagents.

The first synthesis of coniochaetones A and (±)-B: Two benzopyranone derivatives

An efficient synthesis of coniochaetone A and of racemate coniochaetone B was achieved by a short five-step procedure from methyl di-O-methyl-p-orsellinate. The key step is a cascade reaction of 2′-hydroxy-6′-methoxy-4′-methyl-2-(methylsulfinyl)- acetophenone with succindialdehyde in the presence of piperidine which allows the direct building of the tricyclic benzopyranone structure.