57459-36-6 Usage
Description
(3-Phenyl-1,2,4-oxadiazol-5-yl)acetonitrile, with the molecular formula C10H6N4O, is a chemical compound derived from the heterocyclic oxadiazole, which features a five-membered ring structure containing one oxygen and two nitrogen atoms. (3-PHENYL-1,2,4-OXADIAZOL-5-YL)ACETONITRILE holds potential in various fields, including pharmaceuticals, agriculture, materials science, and organic electronics, and may also be of interest for medicinal chemistry research due to its possible biological activity.
Uses
Used in Pharmaceutical Industry:
(3-Phenyl-1,2,4-oxadiazol-5-yl)acetonitrile is used as an intermediate in the synthesis of various bioactive compounds. Its unique structure allows for the development of new drugs with potential applications in treating different medical conditions.
Used in Agricultural Industry:
In the agricultural sector, (3-Phenyl-1,2,4-oxadiazol-5-yl)acetonitrile serves as an intermediate for the production of agrochemicals. Its incorporation into these chemicals can lead to enhanced pest control and crop protection.
Used in Materials Science:
(3-Phenyl-1,2,4-oxadiazol-5-yl)acetonitrile is utilized in the development of novel materials with specific properties, such as improved stability or reactivity, which can be applied in various industrial processes.
Used in Organic Electronics:
(3-PHENYL-1,2,4-OXADIAZOL-5-YL)ACETONITRILE is also used in the field of organic electronics, where its unique properties can contribute to the creation of advanced electronic devices and components with improved performance and functionality.
Used in Medicinal Chemistry Research:
Due to its potential biological activity, (3-Phenyl-1,2,4-oxadiazol-5-yl)acetonitrile is of interest for research in medicinal chemistry. Scientists may explore its interactions with biological systems to develop new therapeutic strategies and compounds with specific pharmacological effects.
Check Digit Verification of cas no
The CAS Registry Mumber 57459-36-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,4,5 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57459-36:
(7*5)+(6*7)+(5*4)+(4*5)+(3*9)+(2*3)+(1*6)=156
156 % 10 = 6
So 57459-36-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H7N3O/c11-7-6-9-12-10(13-14-9)8-4-2-1-3-5-8/h1-5H,6H2
57459-36-6Relevant articles and documents
Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan
Naro, Yuta,Ankenbruck, Nicholas,Thomas, Meryl,Tivon, Yaniv,Connelly, Colleen M.,Gardner, Laura,Deiters, Alexander
, p. 5900 - 5909 (2018/08/04)
Chemical probes of microRNA (miRNA) function are potential tools for understanding miRNA biology that also provide new approaches for discovering therapeutics for miRNA-associated diseases. MicroRNA-21 (miR-21) is an oncogenic miRNA that is overexpressed in most cancers and has been strongly associated with driving chemoresistance in cancers such as renal cell carcinoma (RCC). Using a cell-based luciferase reporter assay to screen small molecules, we identified a novel inhibitor of miR-21 function. Following structure-activity relationship studies, an optimized lead compound demonstrated cytotoxicity in several cancer cell lines. In a chemoresistant-RCC cell line, inhibition of miR-21 via small molecule treatment rescued the expression of tumor-suppressor proteins and sensitized cells to topotecan-induced apoptosis. This resulted in a >10-fold improvement in topotecan activity in cell viability and clonogenic assays. Overall, this work reports a novel small molecule inhibitor for perturbing miR-21 function and demonstrates an approach to enhancing the potency of chemotherapeutics specifically for cancers derived from oncomir addiction.
Synthesis of 5-hydroxymethyl-8-methyl-3-(3-aryl-[1,2,4]oxadiazol-5-yl)-2h- pyrano[2,3-c]pyridin-2-ones and their esters
Zhuravel, Irina O.,Kovalenko, Sergiy M.,Zaremba, Oleg V.,Detistov, Oleksandr S.,Kovalenko, Svitlana S.,Chernykh, Valentin P.
, p. 3778 - 3784 (2008/12/23)
New 5-hydroxymethyl-8-methyl-3-(3-aryl-[1,2,4]oxadiazol-5-yl)-2H-pyrano-[2, 3-c]pyridin-2-ones and their esters were synthesized. The structure of obtained compounds was determined through a complete 1H NMR analysis. Copyright Taylor & Francis Group, LLC.
