574729-25-2

Basic information

• Product Name: tert-Butyl 3-amino-5-nitro-1H-indazole-1-carboxylate
• Synonyms: tert-Butyl 3-amino-5-nitro-1H-indazole-1-carboxylate;3-Amino-5-nitro-indazole-1-carboxylic acid tert-butyl ester
• CAS NO: 574729-25-2
• Molecular Formula: C₁₂H₁₄N₄O₄
• Molecular Weight: 278.26396
• Mol File: 574729-25-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl 3-amino-5-nitro-1H-indazole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 3-amino-5-nitro-1H-indazole-1-carboxylate(574729-25-2)
• EPA Substance Registry System: tert-Butyl 3-amino-5-nitro-1H-indazole-1-carboxylate(574729-25-2)

Safety Data

• Hazardous Substances Data: 574729-25-2(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 3-amino-5-nitro-1H-indazole-1-carboxylate is a chemical compound with the molecular formula C11H14N4O4. It is a derivative of indazole, a five-membered aromatic ring fused to a pyrazine ring. tert-Butyl 3-amino-5-nitro-1H-indazole-1-carboxylate contains a tert-butyl group, an amino group, and a nitro group attached to the indazole ring, as well as a carboxylate group attached to the nitrogen atom. It is often used as a building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals due to its versatile reactivity and potential applications in medicinal chemistry. However, as with any chemical compound, proper handling and precautions should be taken to ensure safety and minimize risk of exposure.

Upstream product

• 41339-17-7 5-nitro-1H-indazol-3-amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 574729-28-5 3-(3-Chlorobenzoylamino)-5-nitroindazole-1-carboxylic acid tert-butyl ester 
• 574729-26-3 tert-butyl 3,5-diamino-1H-indazole-1-carboxylate 
• 1094505-69-7 tert-butyl 3-(benzoyl-amino)-5-nitroindazole-1-carboxylate 
• 1268262-09-4 C₂₀H₂₀N₄O₆ 

Relevant articles and documents

Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele

RAS mutations are found in 30% of all human cancers, with KRAS the most frequently mutated among the three RAS isoforms (KRAS, NRAS, and HRAS). However, directly targeting oncogenic KRAS with small molecules in the nucleotide-binding site has been difficult because of the high affinity of KRAS for GDP and GTP. We designed an engineered allele of KRAS and a covalent inhibitor that competes for GTP and GDP. This ligand-receptor combination demonstrates that the high affinity of GTP and GDP for RAS proteins can be overcome with a covalent inhibitor and a suitably engineered binding site. The covalent inhibitor irreversibly modifies the protein at the engineered nucleotide-binding site and is able to compete with GDP and GTP. This provides a new tool for studying KRAS function and suggests strategies for targeting the nucleotide-binding site of oncogenic RAS proteins.

NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF

The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.

Protein kinase affinity reagents based on a 5-aminoindazole scaffold

Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding elements and immobilized analogs allow selective enrichment of protein kinases from complex mixtures.