5749-67-7 Usage
Uses
Different sources of media describe the Uses of 5749-67-7 differently. You can refer to the following data:
1. Carbasalate Calcium is an analgesic, antipyretic, and anti-inflammatory drug.
2. Salicylate; non-selective cyclo-oxygenase inhibitor; antipyretic; analgesic; antiinflammatory.
Description
Carbasalate calcium is a calcium-urea chelate of aspirin that has analgesic, anti-inflammatory, and antipyretic effects. It reduces carrageenan-induced paw edema in rats.
Chemical Properties
White or almost white, crystalline powder.
Originator
Calurin,Dorsey,US,1959
Manufacturing Process
500 g of finely powdered acetylsalicylic acid and 160 g of calcium carbonate
(precipitated chalk), are intimately mixed and 3,000 cc of water are added.
The mixture is stirred for 15 minutes or until the reaction is completed, which
is indicated by the cessation of the liberation of carbon dioxide. The
temperature is desirably maintained below 20°C by any suitable means. The
mass is allowed to settle until the supernatant liquor is almost clear; this
usually takes about 5 minutes, and the mixture is then filtered to remove
unreacted material. This part of the process is carried out as quickly as
possible so as to minimize any tendency of the calcium aspirin to hydrolyze in
the solution. The filtrate is cooled to about 10°C and 1 to 1.5 volumes of 97% methanol, or pure wood alcohol is added. This causes the calcium aspirin to
precipitate and the mass is then filtered to remove as thoroughly as possible
the mother liquor. The residue of calcium aspirin is then suspended in a
quantity of methanol equivalent to the volume previously used as a
precipitant, and it is allowed to stand there for one hour or more with
occasional or continuous agitation. The mass is again filtered, the filtrate
being employed for the precipitation of calcium aspirin in a later batch. After
the filtering of the first wash liquor, the calcium aspirin is again suspended in
another quantity of methanol of an equivalent volume. This constitutes the
second wash and it is carried out in the same way as the first wash. The
filtrate is employed as a first wash in a later batch and this filtrate in turn is
used, as is the filtrate of the first wash, for the precipitation of more calcium
aspirin. Fresh alcohol is used as a new wash in a later batch and the washes
are carried out in series. After the second wash the calcium aspirin is dried in
a suitable manner, as by passing dry warm air over it, the temperature not
being allowed to rise to such an extent as to decompose the aspirin;
preferably the temperature is not permitted to rise above 50°C, but should be
high enough to avoid deposition of water vapor, and the drying is completed
when there is no longer an odor of methanol.
Check Digit Verification of cas no
The CAS Registry Mumber 5749-67-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,4 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5749-67:
(6*5)+(5*7)+(4*4)+(3*9)+(2*6)+(1*7)=127
127 % 10 = 7
So 5749-67-7 is a valid CAS Registry Number.
InChI:InChI=1/2C9H8O4.CH4N2O.Ca/c2*1-6(10)13-8-5-3-2-4-7(8)9(11)12;2-1(3)4;/h2-5H,1H3,(H,11,12);2-5,11H,1H3;(H4,2,3,4);/q;-1;;+2/p-1
5749-67-7Relevant articles and documents
Method for preparing bi (2-micristin) calcium urea compound
-
Paragraph 0019; 0024; 0025, (2017/03/24)
The invention belongs to the technical field of drug synthesis and particularly relates to a method for preparing a bi (2-micristin) calcium urea compound.The method includes the steps that an acetylsalicylic acid compound (III) is added to aqueous suspension of calcium carbonate in a stirring condition, a reaction is conducted, and an acetylsalicylic acid calcium compound (II) is obtained; urea is added without separation for a complex reaction, reaction mixed liquid is subjected to filter pressing and decompression concentration, and a crude product of a bi (2-micristin) calcium urea compound (I) is obtained; posttreatment is conducted, and a fine product of the bi (2-micristin) calcium urea compound (I) is obtained.The method is stable in process, mild in reaction condition, easy to control, short in production cycle, low in energy consumption, high in yield and stable in product quality, the HPLC content is 99.8% and above, and the single biggest impurity salicylic acid is smaller than 0.1%, posttreatment is simple and convenient, recycled solvent can be continuously applied mechanically, waste gas, wastewater and solid waste are less, production cost is low, and the method is suitable for industrial production.