57496-61-4

Basic information

• Product Name: (1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol
• Synonyms: (1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol;(1R,2R)-trans-1,2-Tetralindiol
• CAS NO: 57496-61-4
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• Mol File: 57496-61-4.mol
• Article Data: 32

Chemical Properties

• Melting Point: 114-115 °C
• Boiling Point: 308.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.260±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.81±0.40(Predicted)
• CAS DataBase Reference: (1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol(57496-61-4)
• EPA Substance Registry System: (1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol(57496-61-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 57496-61-4(Hazardous Substances Data)

Usage

Description

(1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol, also known as tetrahydro-1,2-naphthol, is a chemical compound belonging to the class of naphthalene derivatives. It is a diol, meaning it contains two hydroxyl groups. (1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol has a unique chemical structure and properties, making it a versatile molecule with potential applications in various industries.

Uses

Used in Pharmaceutical and Agrochemical Industries:
(1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a key component in the development of new drugs and agricultural products.
Used in Organic Compound Preparation:
(1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol is also used in the preparation of various organic compounds. Its presence in these compounds can enhance their properties and contribute to their overall effectiveness.
Used as a Reagent in Chemical Reactions:
(1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-naphthalenediol serves as a reagent in various chemical reactions. Its ability to participate in these reactions makes it a valuable tool in the synthesis of other compounds.
Used in Medicinal Chemistry and Drug Discovery:
Due to its unique chemical structure and properties, (1R,2R)-trans-1,2,3,4-tetrahydro-1,2-naphthol has potential applications in the field of medicinal chemistry and drug discovery. Researchers can leverage its characteristics to develop new therapeutic agents and explore its potential in treating various diseases.

Upstream product

• 75-91-2 tert.-butylhydroperoxide 
• 447-53-0 1,2-Dihydronaphthalene 
• 2461-34-9 1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene 
• 18672-77-0 2-acetoxy-3,4-dihydronaphthalen-1(2H)-one 
• 64559-97-3 2-hydroxy-1-tetralone 
• 140134-31-2 (R)-(+)-2-hydroxy-3,4-dihydro-2H-naphthalen-1-one 
• 182822-22-6 (2S)-1-oxo-2-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 64245-04-1 2-bromo-1-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 14211-53-1 trans-naphthalene-1,2,3,4-tetrahydro-1,2-diol 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 2461-34-9 (1R,2S)-1,2-epoxy-3,4-dihydronaphthalene 
• 2461-34-9 1,2-epoxy-3,4-dihydronaphthalene 
• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 
• 667894-33-9 1,2,3,4-tetrahydronaphthalene-1,2-diyl diacetate 

Downstream Products

• 14807-28-4 2-(3-oxopropyl)benzaldehyde 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 89920-57-0 (1S,2R)-cis-1,2-dihydroxy-1,2,3,4-tetrahydronaphthalene 
• 57495-92-8 (1R,2S)-1,2,3,4-tetrahydronaphthalene-1,2-diol 
• 776-79-4 2-(2-carboxyethyl)benzoic acid 
• 7480-36-6 (+/-)-cis-1-amino-2-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 1346229-04-6 benzyl (1R,2R)-2-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamate 
• 1346228-96-3 (1R,2R)-1,2-bis(benzyloxy)-1,2,3,4-tetrahydronaphthalene 
• 54311-89-6 2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine 

Relevant articles and documents

Enantioselective, Stereoconvergent Resolution Copolymerization of Racemic cis-Internal Epoxides and Anhydrides

Unprecedented enantioselective resolution copolymerization of racemic cis-internal epoxides and anhydrides was mediated by dinuclear aluminum complexes with multiple chirality, affording optically active polyesters with two contiguous stereogenic centers, and the unreacted substrates in good enantioselectivity. Unexpected stereoconvergence is observed in this resolution copolymerization, where the selectivity factor for the enantioselective formation of copolymer significantly exceeds the kinetic resolution coefficient based on the unreacted epoxide at various conversions. Catalytic activity and copolymer enantioselectivity are strongly influenced by the phenolate ortho-substituents of the ligand set, as well as the axial linker and its chirality. An enantiopure binaphthol-linked bimetallic AlIII complex allows stereoconvergent access to the stereoregular semi-crystalline polyesters and a concomitant kinetic resolution of the epoxide substrates.

A de novo synthetic method to the access of N-substituted benzazepines

A novel, convenient procedure has been described for the construction of fluorine-containing benzazepines. The synthetic protocol starting from readily available dihydronaphthalene regioisomers is based on oxidative ring olefin bond cleavage followed by r

Oxidative β-Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins

β-Halohydrins bearing transformable halo- and hydroxyl groups, are easily converted into various valuable blocks in organic and pharmaceutical synthesis. A diastereoselective β-halogenation of benzylic alcohols was achieved under simple and low-cost conditions, which provided a direct synthesis of β-halohydrins. The simple reaction conditions, easily available reagents, high diastereoselectivities, and additional oxidant-free make this reaction very attractive and practical.