57536-91-1 Usage
Description
1-(2-NAPHTHYL)PIPERAZINE, with the molecular formula C16H18N2, is a piperazine derivative featuring a naphthalene group attached to the piperazine ring. This chemical compound serves as a versatile building block in the synthesis of pharmaceutical drugs and organic compounds, and has been explored for its potential in treating various mental health conditions as well as in the development of metal complexes and heterocyclic compounds.
Uses
Used in Pharmaceutical Industry:
1-(2-NAPHTHYL)PIPERAZINE is used as a key intermediate in the synthesis of various pharmaceutical drugs due to its unique chemical structure and properties. Its potential antidepressant, anxiolytic, and antipsychotic properties make it a valuable compound in the development of new medications for mental health treatment.
Used in Research Applications:
As a serotonin receptor agonist, 1-(2-NAPHTHYL)PIPERAZINE is utilized in research to study the effects and mechanisms of action of serotonin in the central nervous system. This helps in understanding the role of serotonin in mood regulation and the development of related therapeutic agents.
Used in Metal Complexes:
1-(2-NAPHTHYL)PIPERAZINE has been investigated for its potential as a ligand for metal complexes, which can be used in various applications such as catalysis, materials science, and medicinal chemistry. Its ability to form stable complexes with metals enhances its utility in these fields.
Used in Organic Synthesis:
1-(2-NAPHTHYL)PIPERAZINE serves as an intermediate in the synthesis of various heterocyclic compounds, which are important in the development of new organic molecules with potential applications in pharmaceuticals, agrochemicals, and other industries. Its presence in these compounds contributes to their unique properties and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 57536-91-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,5,3 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 57536-91:
(7*5)+(6*7)+(5*5)+(4*3)+(3*6)+(2*9)+(1*1)=151
151 % 10 = 1
So 57536-91-1 is a valid CAS Registry Number.
57536-91-1Relevant articles and documents
Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines
Mills, L. Reginald,Barrera Arbelaez, Luis Miguel,Rousseaux, Sophie A. L.
supporting information, p. 11357 - 11360 (2017/08/30)
Metal homoenolates, produced via C-C bond cleavage of cyclopropanols, have been extensively investigated as nucleophiles for the synthesis of β-substituted carbonyl derivatives. Herein, we demonstrate that zinc homoenolates can react as carbonyl-electrophiles in the presence of nucleophilic amines to yield highly valuable trans-cyclopropylamines in good yields and high diastereoselectivities. GSK2879552, a lysine demethylase 1 inhibitor currently in clinical trials for the treatment of small cell lung carcinoma, was synthesized using this strategy.
FATTY ACID SYNTHASE INHIBITORS
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Page/Page column 53; 54; 55, (2014/01/07)
Disclosed are compounds having Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, m, and n are defined herein and methods of using the same.
Discovery of imidazole carboxamides as potent and selective CCK1R agonists
Zhu, Cheng,Hansen, Alexa R.,Bateman, Thomas,Chen, Zhesheng,Holt, Tom G.,Hubert, James A.,Karanam, Bindhu V.,Lee, Susan J.,Pan, Jie,Qian, Su,Reddy, Vijay B.G.,Reitman, Marc L.,Strack, Alison M.,Tong, Vincent,Weingarth, Drew T.,Wolff, Michael S.,MacNeil, Doug J.,Weber, Ann E.,Duffy, Joseph L.,Edmondson, Scott D.
scheme or table, p. 4393 - 4396 (2009/04/06)
High-throughput screening revealed diaryl pyrazole 3 as a selective albeit modest cholecystokinin 1 receptor (CCK1R) agonist. SAR studies led to the discovery and optimization of a novel class of 1,2-diaryl imidazole carboxamides. Compound 44, which was profiled extensively, showed good in vivo mouse gallbladder emptying (mGBE) and lean mouse overnight food intake (ONFI) reduction activities.
