5754-27-8Relevant articles and documents
A C2-symmetric pool based flexible strategy: An enantioconvergent synthesis of (+)-valiolamine and (+)-valienamine
Lo, Hong-Jay,Chen, Cheng-Yih,Zheng, Wei-Lin,Yeh, Shang-Ming,Yan, Tu-Hsin
experimental part, p. 2780 - 2785 (2012/07/14)
A new enantioconvergent strategy directed toward the synthesis of glucosidase inhibitors was developed by using a C2-symmetric element within the chiral pool and by applying an iodine-promoted cyclization of an unsaturated carbonimidothioate for the regio- and diastereocontrolled installation of amino and hydroxy units. Not only does this simple flexible strategy provide a convergent concise approach to (+)-valiolamine (1), but it can also be readily adopted for the synthesis of (+)-valienamine (2). Commercially available and cheap C2-symmetric D-tartaric acid served as the chiral building block. Copyright
The enantioselective total synthesis of nemotin
Jian, Ya-Jun,Wu, Yikang
experimental part, p. 811 - 821 (2010/06/20)
The allene-diyne natural product nemotin was synthesized for the first time through an enantioselective route with the stereogenic center at the lactone moiety derived from l-glutamic acid and the allene axis constructed from the corresponding propargylic
Concise synthesis of iminocyclitols via petasis-type aminocyclization
Hong, Zhangyong,Liu, Lei,Sugiyama, Masakazu,Fu, Yu,Wong, Chi-Huey
supporting information; experimental part, p. 8352 - 8353 (2009/10/23)
(Chemical Equation Presented) A two-step method has been developed to synthesize several biologically important iminocyclitols in ca. 44-60percent yields by using Petasis-type condensation. The method is very generaland operationally simple, affording a s
