57544-05-5

Basic information

• Product Name: 2H-1-Benzopyran, 8-methoxy-2-(4-methoxyphenyl)-3-nitro-
• CAS NO: 57544-05-5
• Molecular Formula: C17H15NO5
• Molecular Weight: 313.31
• Mol File: 57544-05-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran, 8-methoxy-2-(4-methoxyphenyl)-3-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran, 8-methoxy-2-(4-methoxyphenyl)-3-nitro-(57544-05-5)
• EPA Substance Registry System: 2H-1-Benzopyran, 8-methoxy-2-(4-methoxyphenyl)-3-nitro-(57544-05-5)

Safety Data

• Hazardous Substances Data: 57544-05-5(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 

Downstream Products

• 92046-59-8 3,3,8-Trimethoxy-2-(4-methoxy-phenyl)-chroman-4-one oxime 
• 91735-29-4 4,4,8-Trimethoxy-2-(4-methoxy-phenyl)-chroman-3-one oxime 
• 121824-26-8 (3aS,4R,9bR)-6-Methoxy-4-(4-methoxy-phenyl)-2-methyl-3a-nitro-1,3a,4,9b-tetrahydro-2H-chromeno[4,3-d]isoxazole 
• 131391-92-9 ethyl 3-<3'-nitro-2'-(4''-methoxyphenyl)-8'-methoxy-benzopyran-3'-yl>-propionate 
• 131391-95-2 spiro <3-(2-(4'-methoxyphenyl))-8-methoxy-benzopyran>-5'-(N-hydroxy)-pyrrolidin-2'-one 
• 113495-54-8 (2R,3S)-8-Methoxy-2-(4-methoxy-phenyl)-3-nitro-chroman 
• 113495-54-8 (2R,3R)-8-Methoxy-2-(4-methoxy-phenyl)-3-nitro-chroman 
• 877-22-5 3-methoxysalicylic acid 
• 91735-21-6 3-Hydroxy-8-methoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 100-09-4 4-methoxybenzoic acid 

Relevant articles and documents

Synthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2 H -chromene derivatives as potent anti-breast cancer agents

A series of 2-aryl-3-nitro-2H-chromenes 4a-u were designed as hybrid analogs of flavanone, β-nitrostyrene and nitrovinylstilbene scaffolds. They were synthesized from the reaction of appropriate β-nitrostyrenes and salicylaldehydes in good yields. In vitro cytotoxic activities of compounds 4a-u were tested against breast cancer cell lines including MCF-7, T-47D and MDA-MB-231. Most compounds exhibited good cytotoxic activity against selected cell lines, being more potent than standard drug etoposide. Representatively, 8-methoxy-3-nitro-2-(4-chlorophenyl)-2H-chromene (4l) with IC50 Combining double low line 0.2 μ4M against MCF-7 cells, was 36-times more potent than etoposide. Apoptosis as a mechanism of cell death for selected compounds 4h and 4l was confirmed morphologically by acridine orange/ethidium bromide double staining and TUNEL analysis, as well as caspase-3 activation assay.