57556-31-7

Basic information

• Product Name: Methyl 4-hydroxy-2-methylbenzoate
• Synonyms: Methyl 4-hydroxy-2-methylbenzoate;4-Hydroxy-2-methylbenzoic acid methyl ester;Methyl 2-methyl-4-hydroxybenzoate
• CAS NO: 57556-31-7
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.1739
• Product Categories: Aromatic Esters
• Mol File: 57556-31-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 106-110℃
• Boiling Point: 275℃
• Flash Point: 117℃
• Appearance: /
• Density: 1.169
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.47±0.18(Predicted)
• CAS DataBase Reference: Methyl 4-hydroxy-2-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-hydroxy-2-methylbenzoate(57556-31-7)
• EPA Substance Registry System: Methyl 4-hydroxy-2-methylbenzoate(57556-31-7)

Safety Data

• Hazardous Substances Data: 57556-31-7(Hazardous Substances Data)

Usage

General Description

Methyl 4-hydroxy-2-methylbenzoate, also known as methyl p-hydroxy-ortho-methylbenzoate, is a chemical compound commonly used as a preservative in various cosmetic and personal care products, as well as in pharmaceutical formulations. It is derived from benzoic acid and has the molecular formula C9H10O3. Methyl 4-hydroxy-2-methylbenzoate possesses antimicrobial properties, which makes it effective in preventing the growth of bacteria and fungi in skincare and haircare products. Methyl 4-hydroxy-2-methylbenzoate is also used as a flavoring agent in food products and as a fragrance ingredient in perfumes and other scented items. Despite its beneficial uses, it is important to use this chemical with caution and in accordance with safety guidelines to avoid potential health risks.

InChI:InChI=1/C9H10O3/c1-6-5-7(10)3-4-8(6)9(11)12-2/h3-5,10H,1-2H3

Upstream product

• 578-39-2 4-hydroxy-2-methylbenzoic acid 
• 922-67-8 propynoic acid methyl ester 
• 67-56-1 methanol 
• 14143-26-1 4-hydroxy-2-methylbenzonitrile 
• 63446-76-4 1-methyl-1,3-bis(trimethylsilyloxy)buta-1,3-diene 
• 201230-82-2 carbon monoxide 
• 133921-27-4 4-iodo-3-methyl-phenol 
• 186581-53-3 diazomethane 
• 35490-07-4 methyl 2-methyl-4-oxocyclohex-2-enecarboxylate 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 104216-19-5 4-ethoxy-2-methyl-benzoic acid methyl ester 
• 35598-05-1 methyl 4-methoxy-2-methylbenzoate 
• 62443-14-5 2-Methyl-4-tetradecyloxy-benzoic acid 
• 52289-54-0 4-methoxysalicylaldehyde 
• 52289-55-1 (4-methoxy-2-methylphenyl)methanol 
• 103323-97-3 4-ethoxy-2-methyl-benzoic acid 
• 1040723-95-2 4-cyclopropylmethoxy-2-methyl-benzoic acid methyl ester 
• 1204301-92-7 4-[3-(4-methoxycarbonyl-3-methylphenoxy)propyl]piperidine-1-carboxylic acid tert-butyl ester 
• 22574-58-9 4-hydroxymethyl-3-methylphenol 
• 1321937-71-6 methyl 2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoate 
• 502606-14-6 benzyl [2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate 
• 502606-18-0 benzyl [5-fluoro-2-methyl-1-(2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)-1H-indol-3-yl]acetate 
• 1321937-95-4 2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoic acid 
• 603108-87-8 2-methyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl chloride 

Relevant articles and documents

NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS

-The present invention relates to new isoindolinone or isobenzofuranone substituted indoles and derivatives of formula (I) wherein the groups R1 to R7, R10 and n have the meanings given in the claims and specification, their use as inhibitors of RAS-family proteins and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

A highly efficient metal-free approach to: Meta - And multiple-substituted phenols via a simple oxidation of cyclohexenones

A novel and efficient metal-free approach to substituted phenols has been disclosed from simple and readily available cyclohexenones and cyclohexenone equivalents. Dimethyl sulfoxide (DMSO), a simple and common organic reagent, was employed as a mild oxidant in this I2-catalysis, which significantly tolerates various substituents including some easily oxidizable or reducible functionalities. The challenging meta- and multiple-substituted phenols could be well prepared by this method. The metal-free and mild oxidation make this protocol very simple, practical, and easy to handle.

METHOD OF MANUFACTURING 4-HYDROXY-2-METHYLBENZOIC ACID DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for manufacturing 4-hydroxy-2-methylbenzoic esters simply in a short time. SOLUTION: There is provided a method for manufacturing a 4-hydroxy-2-methylbenzoic acid derivative (1) by air oxidizing a 2-methyl-4-oxo-2