576-28-3

Basic information

• Product Name: 3-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• Synonyms: 3-Methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; 4(1H)-pyrimidinone, 2,3-dihydro-3-methyl-2-thioxo-
• CAS NO: 576-28-3
• Molecular Formula: C₅H₆N₂OS
• Molecular Weight: 142.1789
• Mol File: 576-28-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 216.4°C at 760 mmHg
• Flash Point: 84.7°C
• Density: 1.38g/cm³
• Vapor Pressure: 0.14mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 3-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(576-28-3)
• EPA Substance Registry System: 3-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(576-28-3)

Safety Data

• Hazardous Substances Data: 576-28-3(Hazardous Substances Data)

Upstream product

• 104369-27-9 3-methyl-2-thioxo-2,3,r-4a,c-5,c-8,c-8a-hexahydro-5,8-methanoquinazolin-4(1H)-one 
• 104369-27-9 3-methyl-2-thioxo-2,3,r-4a,t-5,t-8,c-8a-hexahydro-5,8-methanoquinazolin-4(1H)-one 
• 6327-98-6 2-methylthio-3-methylpyrimidin-4(3H)-one 
• 104308-57-8 (1S,2R,3S,4R)-3-(3-Methyl-thioureido)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 
• 104308-57-8 (1R,2R,3S,4S)-3-(3-Methyl-thioureido)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 

Downstream Products

• 6104-45-6 3-methylpyrimidin-4-one 
• 608-34-4 3-methyluracil 

Relevant articles and documents

New 1,3-diazadienes used in heterocyclic synthesis

The synthesis of dihydropyrimidines, dihydropyrimidinones and thiadiazine-1,1-dioxides starting from neutral or cationic 2-methylthio-1,3- diazadienes is described. Addition of H2S followed by loss of methanethiol led to the corresponding thiocarbonyl compounds.

FUSED-SKELETON SATURATED SIX-MEMBERED 1,3-N,O, N,N AND N,S HETEROCYCLES, FUSED-SKELETON ARYL-SUBSTITUTED SATURATED ISOINDOLONES

In the introduction, a brief survey is given of the main types of fused-skeleton saturated six-membered 1,3-heterocycles serving as model compounds in our earlier investigations and as starting compounds in the present studies.The synthesis and conformational analysis of aryl-substituted fused-skeleton saturated 1,3-oxazines and of aryl-substituted hetero-condensed saturated isoindolones are treated. cis-trans isomerization in the saturated isoindolone moiety of the resulting tricyclic, tetracyclic and pentacyclic systems is discussed in connection with the ring-closure reactions of cis- and trans-1,2-disubstituted 1,2- and 1,3-difunctional alicyclic compounds to give alicycle-fused six-membered 1,3-heterocycles.The cycloaddition reactions of dihydro-1,3 and 3,1-oxazines and the conformations of the alicycle-fused tetrahydrooxazine-azetidinone derivatives obtained are presented.Methods are given for the preparation of saturated thiazolo- and thiazinoquinazolinones.Unambiguous, mainly one-pot syntheses for the preparation of 1,3-heterocycles by a retro Diels-Alder method are discussed.