57601-61-3

Basic information

• Product Name: 6,6,10,10-Tetramethyl-2H,6H,10H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one
• Synonyms: 6,6,10,10-Tetramethyl-2H,6H,10H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one;Dipetalolactone;Hortilin;Hortiline
• CAS NO: 57601-61-3
• Molecular Formula: C19H18O4
• Molecular Weight: 310.34382
• Mol File: 57601-61-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,6,10,10-Tetramethyl-2H,6H,10H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,6,10,10-Tetramethyl-2H,6H,10H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one(57601-61-3)
• EPA Substance Registry System: 6,6,10,10-Tetramethyl-2H,6H,10H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one(57601-61-3)

Safety Data

• Hazardous Substances Data: 57601-61-3(Hazardous Substances Data)

Upstream product

• 2732-18-5 5,7-dihydroxy-2H-chromen-2-one 
• 31525-67-4 dimethylacetal of 3-methyl-3-hydroxybutyraldehyde 
• 107-86-8 3,3-dimethyl acrylaldehyde 

Relevant articles and documents

Synthesis and cytotoxicity of coumarin derivatives and nordentatin

Nordentatin and 10 coumarin derivatives were synthesized and evaluated for cytotoxicity. Compounds 6, 7, 9 and 13 showed cytotoxicity against the NCI-H187 cell line with IC50 value ranging of 3-7 μg/mL. Among synthesized coumarins, compounds 4 and 13 demonstrated cytotoxicity against the KB cell line with IC50 values of 3.94 and 6.44 μg/mL, respectively. Fortunately, coumarins 4 and 7 may be one of the new lead compounds for the development of anticancer agents due to reason that they showed weak and inactive against normal cells.

SYNTHESIS OF NEW PYRANOCOUMARINS

As a result of condensing 5,7-dihydroxy-4-methylcoumarin with dimethyl acetal-3-methylbuten-2-al, 4-methyl-5-hydroxyseseline, 4-methyldipetalolactone and 5-hydroxy-4,10,10-trimethyl-2H,8H-benzodipyran-2-one have been obtained.Condensation of 5,7-hydroxycoumarin with this acetal leads to 5-hydroxyseseline, dipetalolactone and 5-hydroxy-10,10-dimethyl-2H,8H-benzodipyran-2-one