57606-64-1

Basic information

• Product Name: Phenol, 3-fluoro-, 4-methylbenzenesulfonate
• CAS NO: 57606-64-1
• Molecular Formula: C13H11FO3S
• Molecular Weight: 266.293
• Mol File: 57606-64-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phenol, 3-fluoro-, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3-fluoro-, 4-methylbenzenesulfonate(57606-64-1)
• EPA Substance Registry System: Phenol, 3-fluoro-, 4-methylbenzenesulfonate(57606-64-1)

Safety Data

• Hazardous Substances Data: 57606-64-1(Hazardous Substances Data)

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 372-20-3 3-fluorophenol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 396-64-5 3,3'-difluoro-biphenyl 
• 455-38-9 3-fluorobenzoic acid 
• 20000-61-7 2-(3-fluorophenyl)-benzo[d]oxazole 
• 23588-07-0 diethyl (3-fluorophenyl)phosphonate 

Relevant articles and documents

Effect of charged and ortho substituents on 17O NMR chemical shifts of substituted phenyl tosylates in DMSO

The 17O nuclear magnetic resonance chemical shifts for 31 ortho-substituted, para-substituted, and meta-substituted phenyl esters of 4-methylbenzenesulfonic acid (phenyl tosylates, 4-CH3-C6H4SO2OC6H4-X) with the neutral and charged substituents in phenoxy part were measured in DMSO-d6 at 50°C. The chemical shifts, δ(17O), of the sulfonyl (SO2) and single-bonded phenoxy (O─Ph) oxygens for para and meta derivatives in the case of neutral substituents showed a good correlation with the Taft σI and σ°R substituent constants. The influence of the ortho substituents on the δ(17O) chemical shifts of the sulfonyl oxygens and single-bonded phenoxy oxygens was found to be described well with the Charton equation: δ(17O)ortho?=?δ(17O)H?+?ρI σI?+?ρRσ°R?+?δEBs when the data treatment was performed separately for electron-donating +R substituents and electron-withdrawing ?R substituents. The substituent constants, σ°X±, for the charged substituents (4-N+(CH3)3I?, 3-N+(CH3)3I?, 2-N+(CH3)3I?, 4-COO?N+Bu4, 3-COO?N+Bu4, 2-COO?N+Bu4) calculated from the δ(17O) chemical shifts for phenyl tosylates in DMSO prove that in DMSO, the compounds involving charged substituents are predominantly in ion pair form and not dissociated into free ions. The same conclusion was drawn recently from the carbonyl IR stretching frequencies, νCO, and the carbonyl carbon 13C chemical shifts for substituted phenyl benzoates, C6H5CO2C6H4-X, in DMSO. It was shown that for ion pairs of the charged substituents in DMSO and concentrated aqueous salt solution, the same substituent constant, σ°X±, could be used.

Dimerization of Aryl Sulfonates by in situ Generated Nickel(0)

A mild and user-friendly nickel-catalyzed method for the reductive homocoupling of aromatic tosylates is presented. The reaction proceeds between room temperature and 60 °C, with stable substrates (ArOTs) easily prepared from inexpensive and commercially available phenols or naphthols. It relies on a catalytic amount (10 mol%) of a robust catalyst (NiBr2bipy) that does not require the preparation of sensitive organometallic intermediates. Yields are good to excellent.

A new preparative method of aryl sulfonate esters by using cyclic organobismuth reagents

A new method for the preparation of aryl sulfonate esters by using a cyclic pentavalent bismuth is described. Aryl sulfonate esters are formed in good to high yields by treating 10-arylphenothiabismine 5,5-dioxides, m-chloroperoxybenzoicacid (m-CPBA)and various sulfonic acids in dichloromethane.