5765-76-4

Basic information

• Product Name: (2E)-3-(4-chlorophenyl)-2-sulfanylprop-2-enoic acid
• Synonyms: (2E)-3-(4-Chlorophenyl)-2-sulfanylacrylic acid; 2-propenoic acid, 3-(4-chlorophenyl)-2-mercapto-, (2E)-
• CAS NO: 5765-76-4
• Molecular Formula: C₉H₇ClO₂S
• Molecular Weight: 214.6687
• Mol File: 5765-76-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 376.3°C at 760 mmHg
• Flash Point: 181.4°C
• Density: 1.423g/cm³
• Vapor Pressure: 2.48E-06mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: (2E)-3-(4-chlorophenyl)-2-sulfanylprop-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(4-chlorophenyl)-2-sulfanylprop-2-enoic acid(5765-76-4)
• EPA Substance Registry System: (2E)-3-(4-chlorophenyl)-2-sulfanylprop-2-enoic acid(5765-76-4)

Safety Data

• Hazardous Substances Data: 5765-76-4(Hazardous Substances Data)

Usage

Description

(2E)-3-(4-chlorophenyl)-2-sulfanylprop-2-enoic acid, also known as tiaprofenic acid, is a non-steroidal anti-inflammatory drug (NSAID) that is used to relieve pain, inflammation, and fever. It functions by inhibiting the production of prostaglandins, which are substances in the body that cause pain and inflammation.
Used in Pharmaceutical Industry:
(2E)-3-(4-chlorophenyl)-2-sulfanylprop-2-enoic acid is used as an analgesic and anti-inflammatory agent for the treatment of conditions such as arthritis, menstrual pain, and migraines. It is available in various formulations, including tablets, capsules, and injections, and is generally well-tolerated with a low risk of side effects when used as directed.
However, like other NSAIDs, (2E)-3-(4-chlorophenyl)-2-sulfanylprop-2-enoic acid may be associated with an increased risk of cardiovascular and gastrointestinal side effects in some individuals. Therefore, it should be used cautiously and under the supervision of a healthcare professional.

Upstream product

• 23517-83-1 5-(4-chlorophenylmethylene)-3-methyl-4-oxo-2-thioxothiazolidine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 104484-35-7 2-[(E)-1-Carboxy-2-(4-chloro-phenyl)-vinylsulfanyl]-3-oxo-butyric acid ethyl ester 
• 104484-22-2 5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-2-methyl-6-oxo-5,6-dihydro-[1,4]oxathiine-3-carboxylic acid ethyl ester 

Relevant articles and documents

The chelating behaviour of 3-(4-X-phenyl)-2-sulfanylpropenoic acids with the PbII ion - Relevance of the lone electron pair in the supramolecular structures of the 2:1 complexes

The interaction of 3-(4-X-phenyl)-2-sulfanylpropenoic acids [H 2(X-pspa); X = -F, -Cl, -Br, -I, -OCH3, -OCF3, -OH] with lead(II) acetate in an alcoholic medium was explored in the search for new chelating agents for the Pb2+ ion. The direct reactions afforded [Pb(X-pspa)] complexes in yields of 67 (X = -Br) to 95 % (X = -OCH 3). When the PbII/H2(X-pspa) reaction was performed in the presence of diisopropylamine (Q), the derivatives [HQ] 2[Pb(X-pspa)2] (X = Cl, Br) were obtained. All of the complexes were characterized by spectrometric (FAB-MS and ESI-MS) and spectroscopic (IR, 1H and 13C NMR spectroscopy) methods and these showed the permanence of the O,S coordination of the ligands to the metal ion in dimethyl sulfoxide (DMSO) solution. H2(Cl-pspa), [HQ]2[Pb(Cl-pspa)2] and [HQ]2[Pb(Br-pspa) 2] were also fully characterized in the solid state by X-ray diffraction. The importance of the stereochemically active lone electron pair of the PbII ion in the supramolecular arrangement of [HQ] 2[Pb(X-pspa)2] (X = Cl, Br) is discussed. The characteristics of complexes formed by 3-(4-X-phenyl)-2-sulfanylpropenoic acids with lead(II) cations have been explored both in the solid state and in solution. The importance of the stereochemically active lone electron pair of the PbII ion in the supramolecular arrangement of [HQ] 2[Pb(X-pspa)2] (X = Cl, Br; Q = diisopropylamine) is discussed. Copyright